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肺部炎症的生物学机制及其与血清阳性类风湿性关节炎的关联。

Biological mechanisms of pulmonary inflammation and its association with seropositive rheumatoid arthritis.

作者信息

Yang Peiyue, Song Yuqing, Li Mingwei

机构信息

Department of Rheumatism and Immunology, Fuxing Hospital affiliated to Capital Medical University, Beijing, China.

Department of Emergency, Suzhou Hospital of Traditional Chinese Medicine, Suzhou, China.

出版信息

Front Immunol. 2025 May 23;16:1530753. doi: 10.3389/fimmu.2025.1530753. eCollection 2025.

DOI:10.3389/fimmu.2025.1530753
PMID:40486510
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12141282/
Abstract

Although the pathogenesis of seropositive rheumatoid arthritis (RA) remains unclear, studies suggest that pulmonary inflammation-related biological mechanisms play a significant role in its development. This review thoroughly explores the mechanisms underlying early pulmonary lesions in seropositive RA, focusing on the mucosal barrier hypothesis, neutrophil extracellular traps, pathogenic microbial infections like COVID-19, Vitamin D, the microbiome and gut-lung axis, inhalation exposures and chronic pulmonary diseases. This study seeks to provide novel insights and theoretical foundations for the prevention and treatment of seropositive rheumatoid arthritis.

摘要

尽管血清阳性类风湿性关节炎（RA）的发病机制尚不清楚，但研究表明，与肺部炎症相关的生物学机制在其发展中起重要作用。本综述深入探讨了血清阳性RA早期肺部病变的潜在机制，重点关注黏膜屏障假说、中性粒细胞胞外陷阱、如COVID-19等致病性微生物感染、维生素D、微生物群和肠-肺轴、吸入暴露和慢性肺部疾病。本研究旨在为血清阳性类风湿性关节炎的预防和治疗提供新的见解和理论基础。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e049/12141282/7e37c7bc8c59/fimmu-16-1530753-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e049/12141282/a8c3235a116b/fimmu-16-1530753-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e049/12141282/7e37c7bc8c59/fimmu-16-1530753-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e049/12141282/a8c3235a116b/fimmu-16-1530753-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e049/12141282/7e37c7bc8c59/fimmu-16-1530753-g002.jpg

相似文献

[1]
Biological mechanisms of pulmonary inflammation and its association with seropositive rheumatoid arthritis.

Front Immunol. 2025-5-23

[2]
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[3]
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[4]
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[5]
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[6]
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[7]
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[8]
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[9]
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[10]
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本文引用的文献

[1]
Neutrophil extracellular traps (NETs) are increased in rheumatoid arthritis-associated interstitial lung disease.

Respir Res. 2025-1-22

[2]
SARS-CoV-2 induced vitamin D deficiency and psychological stress: a manifestation of autoimmune disease onset.

Front Immunol. 2024

[3]
Rheumatoid Arthritis-Associated Interstitial Lung Disease (RA-ILD): Update on Prevalence, Risk Factors, Pathogenesis, and Therapy.

Curr Rheumatol Rep. 2024-12

[4]
Recognition and control of neutrophil extracellular trap formation by MICL.

Nature. 2024-9

[5]
The impact of periodontitis and periodontal treatment on rheumatoid arthritis outcomes: an exploratory clinical trial.

Rheumatology (Oxford). 2025-4-1

[6]
Impaired balance between neutrophil extracellular trap formation and degradation by DNases in COVID-19 disease.

J Transl Med. 2024-3-7

[7]
Periodontitis and rheumatoid arthritis-Global efforts to untangle two complex diseases.

Periodontol 2000. 2024-2-27

[8]
Rheumatoid arthritis.

Lancet. 2023-11-25

[9]
C/EBPβ: The structure, regulation, and its roles in inflammation-related diseases.

Biomed Pharmacother. 2023-12-31

[10]
Interleukin 6: at the interface of human health and disease.

Front Immunol. 2023

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