Rezapour Sadegh, Shiravand Mustafa, Mardani Mahnaz
Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.
Faculty of Physical Education and Sports Sciences, Gilan University, Gilan, Iran.
Biotechnol Appl Biochem. 2018 Nov;65(6):761-767. doi: 10.1002/bab.1689. Epub 2018 Sep 19.
One of the epigenetic-modifying factors is regular and continuous physical activity. This article attempts to investigate the effects of physical activity and exercise on changes in histone proteins and gene expression, as well as the effect of these exercises on the prevention of certain cancers and the ejection of age-related illnesses and cellular oxidation interactions. All of this is due to epigenetic changes and gene expression. Most studies have reported the positive effects of regular exercises on the expression of histone proteins. DNA methylation and the prevention of certain diseases such as cancer and respiratory diseases, caused by antioxidative interactions that occur more often in the elderly, have been studied.
表观遗传修饰因素之一是规律且持续的体育活动。本文试图研究体育活动和锻炼对组蛋白变化和基因表达的影响,以及这些锻炼对预防某些癌症、抵御与年龄相关疾病和细胞氧化相互作用的效果。所有这些都归因于表观遗传变化和基因表达。大多数研究都报告了规律锻炼对组蛋白表达的积极影响。人们已经对DNA甲基化以及由老年人中更常发生的抗氧化相互作用所引起的某些疾病(如癌症和呼吸系统疾病)的预防进行了研究。