人类睡眠的分子遗传学
The molecular genetics of human sleep.
作者信息
Zhang Luoying, Fu Ying-Hui
机构信息
Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology and Institute of Brain Research, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Department of Neurology, University of California, San Francisco, California.
出版信息
Eur J Neurosci. 2020 Jan;51(1):422-428. doi: 10.1111/ejn.14132. Epub 2018 Sep 20.
It has been known for many years that genetic influences account for some of the individual differences in human sleep parameters, but the underlying molecular mechanisms remain unclear. With major advances of molecular biology and the recognition of heritable sleep behaviors in humans over the past 30 years, a number of genetic variants have been identified to be associated with human sleep timing, duration and quality, both in healthy individuals and under pathological conditions. Some of these variants were further validated and characterized in animal models, shedding light on the mechanism of how these variants likely alter sleep in humans, which may provide new insights into developing more effective treatments to improve human sleep.
多年来人们已经知道，基因影响在人类睡眠参数的个体差异中占了一定比例，但潜在的分子机制仍不清楚。随着分子生物学的重大进展以及在过去30年中对人类可遗传睡眠行为的认识，已经鉴定出许多基因变异与人类的睡眠时间、时长和质量相关，无论是在健康个体还是在病理状况下。其中一些变异在动物模型中得到了进一步验证和表征，从而揭示了这些变异可能如何改变人类睡眠的机制，这可能为开发更有效的改善人类睡眠的治疗方法提供新的见解。
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