Department of Neurology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, 10029, USA.
Department of Neuroscience, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, 10029, USA; The Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, 10029, USA.
Neuroimage. 2018 Dec;183:565-573. doi: 10.1016/j.neuroimage.2018.08.052. Epub 2018 Aug 23.
Episodic memory, everyday memory for events, is frequently impaired in patients with epilepsy. We tested patients undergoing intracranial electroencephalography (intracranial EEG) monitoring for the treatment of medically-refractory epilepsy on a well-characterized paradigm that requires episodic memory. We report that an anatomically diffuse network characterized by theta-band (4-7 Hz) coherence is activated at the time of target selection in a task that requires episodic memory. This distinct network of oscillatory activity is absent when episodic memory is not required. Further, the theta band synchronous network was absent in electrodes within the patient's seizure onset zone (SOZ). Our data provide novel empirical evidence for a set of brain areas that supports episodic memory in humans, and it provides a pathophysiologic mechanism for the memory deficits observed in patients with epilepsy.
情景记忆，即对事件的日常记忆，在癫痫患者中经常受损。我们在一个经过充分特征描述的范式上测试了正在接受颅内脑电图 (intracranial EEG) 监测以治疗药物难治性癫痫的患者，该范式需要情景记忆。我们报告说，在需要情景记忆的任务中，在目标选择时，一个以θ波段（4-7 Hz）相干性为特征的解剖弥散网络被激活。当不需要情景记忆时，这种独特的振荡活动网络就不存在。此外，在患者的癫痫发作起始区 (SOZ) 内的电极中也不存在θ波段同步网络。我们的数据为一组支持人类情景记忆的大脑区域提供了新的经验证据，并为癫痫患者观察到的记忆缺陷提供了一种病理生理机制。
