学龄期及以后早产儿的神经发育结局

Neurodevelopmental Outcomes of Preterm Children at School Age and Beyond.

作者信息

Synnes Anne, Hicks Matthew

机构信息

Neonatal Follow-Up Program, British Columbia's Women's Hospital, University of British Columbia, Room 1R16, 4500 Oak Street, Vancouver, British Columbia V6H 3N1, Canada.

Department of Pediatrics, Neonatal Intensive Care Unit, University of Alberta, 5027 Diagnosis and Treatment Centre, Royal Alexander Hospital, 10240 Kingsway Northwest, Edmonton, Alberta T5H 3V9, Canada.

出版信息

Clin Perinatol. 2018 Sep;45(3):393-408. doi: 10.1016/j.clp.2018.05.002.

DOI:10.1016/j.clp.2018.05.002

PMID:30144845

Abstract

Despite improved survival of preterm infants, there has not been an equivalent improvement in long-term neurodevelopmental outcomes. Adverse neurodevelopmental outcome rates and severity are inversely related to the degree of prematurity, but only 1.6% are born very preterm and the motor, cognitive, behavioral, and psychiatric disabilities in the large moderate and late preterm population have a greater impact. The disability-free preterm adult has a lower educational achievement and income but similar health-related quality of life to term controls. Reducing the long-term neurodevelopmental impact of prematurity is the next frontier of neonatal care.

摘要

尽管早产儿的存活率有所提高，但长期神经发育结局并未得到同等程度的改善。不良神经发育结局的发生率和严重程度与早产程度呈负相关，但只有1.6%的婴儿是极早产儿，而大量中度和晚期早产儿群体中的运动、认知、行为和精神残疾影响更大。无残疾的早产成年人教育成就和收入较低，但与足月对照组的健康相关生活质量相似。降低早产对神经发育的长期影响是新生儿护理的下一个前沿领域。