Eveleens R D, Gerasimidis K, Chourdakis M, Huysentruyt K, Koletzko B, Hulst J M, Joosten K F M
Department of Pediatrics and Pediatric Surgery, Intensive Care Unit, Erasmus Medical Centre - Sophia Children's Hospital, Rotterdam, The Netherlands.
Human Nutrition, School of Medicine, College of Medicine, Veterinary and Life Sciences, Royal Hospital for Sick Children, University of Glasgow, Glasgow, United Kingdom.
Clin Nutr ESPEN. 2018 Oct;27:75-78. doi: 10.1016/j.clnesp.2018.06.006. Epub 2018 Jul 6.
BACKGROUND & AIMS: At the 38th annual ESPEN congress in The Hague, the Netherlands, the Special Interest Group (SIG) in Paediatrics presented data about current research activities in the field of paediatric nutrition which are performed worldwide and translated this to future research perspectives.
Extensive search of all registered observational and interventional clinical trials in the database ClinicalTrials.gov using the search terms: children nutrition, paediatrics nutrition and children feeding.
A total of 717 studies were found; 173 were duplicates and 114 included adult participants and were therefore excluded. Hence, 430 remained for analysis, of which 69% were randomized controlled trials. The most investigated research topic was nutrition in specific diseases (n = 98), followed by obesity (n = 92), and studies including premature infants (n = 48). The overall median estimated enrolment of children in the trials was 150 children [IQR 50-365]. There were 44 studies in which >1000 participants will be enrolled and six studies with >10,000 participants. Studies including >1000 participants were primarily performed in North America (39%), Africa (27%), and Europe (16%).
This SIG report showed that 430 clinical nutrition trials in paediatrics are registered and current research focusses primarily on specific diseases and obesity. The SIG paediatrics encourages future research to invest in well-controlled interventional trials.
在荷兰海牙举行的第38届欧洲临床营养与代谢学会（ESPEN）年会上，儿科学特别兴趣小组（SIG）展示了全球范围内儿科营养领域当前的研究活动数据，并将其转化为未来的研究前景。
在ClinicalTrials.gov数据库中使用搜索词“儿童营养”“儿科营养”和“儿童喂养”对所有注册的观察性和干预性临床试验进行广泛搜索。
共找到717项研究；173项为重复研究，114项纳入了成人参与者，因此被排除。因此，剩下430项进行分析，其中69%为随机对照试验。研究最多的主题是特定疾病的营养（n = 98），其次是肥胖（n = 92），以及包括早产儿的研究（n = 48）。试验中儿童的总体估计入组中位数为150名儿童[四分位间距50 - 365]。有44项研究将纳入超过1000名参与者，6项研究将纳入超过10000名参与者。纳入超过1000名参与者的研究主要在北美（39%）、非洲（27%）和欧洲（16%）进行。
该SIG报告显示，已注册430项儿科临床营养试验，当前研究主要集中在特定疾病和肥胖方面。SIG儿科学鼓励未来的研究投资于严格控制的干预试验。
