经聚多巴胺-多壁碳纳米管修饰的玻碳电极用于生物体液中生物化合物的同时电化学测定。
Modified glassy carbon electrode with Polydopamine-multiwalled carbon nanotubes for simultaneous electrochemical determination of biocompounds in biological fluids.
机构信息
Analytical Research Laboratory, Department of Chemistry, University of Sistan and Baluchestan, Zahedan, P.O. Box 98135-674, Iran.
Analytical Research Laboratory, Department of Chemistry, University of Sistan and Baluchestan, Zahedan, P.O. Box 98135-674, Iran.
出版信息
J Pharm Biomed Anal. 2018 Nov 30;161:66-72. doi: 10.1016/j.jpba.2018.08.034. Epub 2018 Aug 17.
In this study, a simple modified glassy carbon electrode with Polydopamine-multiwalled carbon nanotubes (GCE/PDA-MWCNTs) is described for selective and sensitive simultaneous voltammetric determination of dopamine (DA), acetaminophen (AC), and xanthine (XN). A detailed investigation by field emission scanning electron microscopy, Fourier transform infrared spectroscopy and electrochemistry methods such as cyclic voltammetry (CV), electrochemical impedance spectroscopy, differential pulse voltammetry (DPV) and chronoamperometry are performed in order to elucidate the preparation process and properties of the GCE/ PDA-MWCNTs. The proposed modified electrode displays intense and indelible electrooxidation response for simultaneous determination of DA, AC, and XN to three well-separated peaks in the potential range from 0.0 to 0.8 V/Ag/AgCl using CV and DPV methods in phosphate buffer solution with pH 7.0. Under the optimum conditions, detection limits of 20, 30 and 50 nM were obtained for DA, AC and XN, respectively. Moreover, GCE/PDA-MWCNTs was successfully used for simultaneous determination of DA, AC and XN in real samples.
在这项研究中，描述了一种简单的修饰玻碳电极，其具有聚多巴胺-多壁碳纳米管（GCE/PDA-MWCNTs），可用于选择性和灵敏的同时伏安法测定多巴胺（DA）、对乙酰氨基酚（AC）和黄嘌呤（XN）。通过场发射扫描电子显微镜、傅里叶变换红外光谱和电化学方法（如循环伏安法（CV）、电化学阻抗谱、差分脉冲伏安法（DPV）和计时安培法）进行了详细的研究，以阐明 GCE/PDA-MWCNTs 的制备过程和性质。所提出的修饰电极对 DA、AC 和 XN 的同时测定表现出强烈且不可磨灭的电氧化响应，在 pH 7.0 的磷酸盐缓冲溶液中，使用 CV 和 DPV 方法，在 0.0 至 0.8 V/Ag/AgCl 的电位范围内可得到三个完全分离的峰。在最佳条件下，DA、AC 和 XN 的检测限分别为 20、30 和 50 nM。此外，GCE/PDA-MWCNTs 成功地用于实际样品中 DA、AC 和 XN 的同时测定。
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