Anand Priyanka, Sarin Namrata, Butti Amul K, Singh Sompal
Pathology Department, Hindurao Hospital and NDMC Medical college, New Delhi, India.
Gulf J Oncolog. 2018 May;1(27):64-69.
Phyllodes tumor is a rare fibroepithelial neoplasm of the breast and constitutes 0.3-0.5% of all breast tumors. They are usually benign and only few of them undergo malignant transformation. Benign or borderline phyllodes tumor typically never recur however, malignant phyllodes tumors do have a recurrence and a metastatic potential. Differentiating these two groups is of prime importance for proper management of the patient. We report a rare case of Malignant Phyllodes tumor in an 18 year old female. She presented with a left breast lump which was gradually increasing in size. There was no significant past or family history. Physical examination revealed a 10x10 cm mass which involved the entire left breast. There was no axillary or supraclavicular lymphadenopathy. On fine needle aspiration cytology, a diagnosis suggestive of an atypical cytology (C3) was given and patient was advised to undergo urgent biopsy and on histopathological examination a possibility of malignant phyllodes tumor was rendered. Following this, lumpectomy was performed and a diagnosis of Malignant Phyllodes tumor was confirmed. Within two months of surgery patient had a recurrence of a huge breast lump with overlying skin ulcerations and underwent a left simple mastectomy. Patient is currently under follow up period and free of disease. A definitive preoperative diagnosis is of utmost importance in correct surgical management of the patient and in order to avoid local recurrences.
叶状肿瘤是一种罕见的乳腺纤维上皮性肿瘤,占所有乳腺肿瘤的0.3 - 0.5%。它们通常是良性的,只有少数会发生恶性转化。良性或交界性叶状肿瘤通常不会复发,然而,恶性叶状肿瘤确实有复发和转移的可能性。区分这两组对于患者的正确管理至关重要。我们报告一例18岁女性的罕见恶性叶状肿瘤病例。她因左乳肿块就诊,肿块大小逐渐增大。既往史和家族史均无明显异常。体格检查发现一个10×10厘米的肿块,累及整个左乳。腋窝及锁骨上无淋巴结肿大。细针穿刺细胞学检查提示非典型细胞学(C3),建议患者紧急活检,组织病理学检查考虑为恶性叶状肿瘤。此后,行肿块切除术,确诊为恶性叶状肿瘤。术后两个月,患者左乳出现巨大肿块伴皮肤溃疡复发,遂行左乳单纯切除术。患者目前处于随访期,无疾病复发。明确的术前诊断对于患者的正确手术管理以及避免局部复发至关重要。