促肾上腺皮质激素及相关肽对内侧隔区自我刺激的影响。

Effects of ACTH and related peptides on medial septal self-stimulation.

作者信息

Gower A J, Broekkamp C L, van Delft A M

出版信息

Pharmacol Biochem Behav. 1986 May;24(5):1253-6. doi: 10.1016/0091-3057(86)90180-2.

Abstract

The effects of ACTH1-24, ACTH4-10, the ACTH4-9 analog Org 2766 and [D-Phe7] ACTH4-10 on medial septal self-stimulation were determined in the rat following intracerebroventricular (ICV) injections. Self-stimulation rates were increased by 0.01-10 micrograms ACTH1-24 or 0.1-10 micrograms ACTH4-10, but not by Org 2766 or [D-Phe7] ACTH4-10. A dose of 1 microgram ACTH1-24 ICV did not affect open field behaviour. Subcutaneous administration of 1 microgram ACTH1-24 did not influence self-stimulation in the septum. Thus, the ACTH1-24 effect appears to be a central effect and provides evidence for an influence of ACTH containing pathways on structures involved in maintaining self-stimulation behavior. A possible role of opiate receptors and dopaminergic neurons in this effect of ACTH1-24 is also discussed.

摘要

在大鼠脑室内（ICV）注射后，测定了促肾上腺皮质激素1-24（ACTH1-24）、促肾上腺皮质激素4-10（ACTH4-10）、促肾上腺皮质激素4-9类似物Org 2766和[D-苯丙氨酸7]促肾上腺皮质激素4-10对内侧隔区自我刺激的影响。0.01 - 10微克的ACTH1-24或0.1 - 10微克的ACTH4-10可提高自我刺激率，但Org 2766或[D-苯丙氨酸7]促肾上腺皮质激素4-10则无此作用。1微克ACTH1-24脑室内注射剂量不影响旷场行为。皮下注射1微克ACTH1-24不影响隔区的自我刺激。因此，ACTH1-24的作用似乎是一种中枢作用，并为含ACTH的通路对维持自我刺激行为相关结构的影响提供了证据。还讨论了阿片受体和多巴胺能神经元在ACTH1-24这一作用中的可能作用。