成年雄性Wistar大鼠背侧不动反应的调节：促肾上腺皮质激素4-10和[D-苯丙氨酸7]促肾上腺皮质激素4-10的相反作用。

The modulation of the dorsal immobility response in the adult male Wistar rat: the opposite effects of ACTH4-10 and [D-Phe7]ACTH4-10.

作者信息

Meyer M E, Bohus B

出版信息

Behav Neural Biol. 1983 Jul;38(2):194-204. doi: 10.1016/s0163-1047(83)90198-x.

Abstract

A series of experiments were conducted to determine the behavioral effect of ACTH4-10 and [D-Phe7]ACTH4-10 on the dorsal immobility response (DIR) in adult male Wistar rats. Both peripheral and central injections of ACTH4-10 attenuated the duration of DIR, whereas, peripherally injected [D-Phe7]ACTH4-10 resulted in the potentiation of this response. The effect of peripherally administered ACTH4-10 was dose dependent in the range of 0.2 to 20 micrograms. These results, in part, extend the prior findings on the modulation of various learned and species-typical behaviors by ACTH-related peptides to a complex state of behavioral inhibition and immobility.

摘要

进行了一系列实验，以确定促肾上腺皮质激素4-10（ACTH4-10）和[D-苯丙氨酸7]促肾上腺皮质激素4-10对成年雄性Wistar大鼠背侧不动反应（DIR）的行为影响。外周和中枢注射ACTH4-10均能缩短DIR的持续时间，而外周注射[D-苯丙氨酸7]ACTH4-10则会增强这种反应。外周给予ACTH4-10的作用在0.2至20微克范围内呈剂量依赖性。这些结果在一定程度上把先前关于促肾上腺皮质激素相关肽对各种习得行为和物种典型行为的调节的研究结果扩展到行为抑制和不动的复杂状态。