Crammer J L
Psychol Med. 1986 May;16(2):451-5. doi: 10.1017/s0033291700009284.
A woman with a 5-year history of frequently recurrent depressions responded poorly to the usual antidepressants. She had a raised plasma cortisol and was made worse by progesterone or by ACTH. An oestradiol/testosterone implant every 4 months abolished all symptoms for at least 8 years, and plasma cortisol returned to normal. This case is relevant to an understanding of premenstrual syndromes and the genesis of depressive illness.
一位有5年频繁复发性抑郁症病史的女性对常规抗抑郁药反应不佳。她的血浆皮质醇升高，使用孕酮或促肾上腺皮质激素会使病情加重。每4个月植入一次雌二醇/睾酮可消除所有症状至少8年，且血浆皮质醇恢复正常。该病例有助于理解经前综合征和抑郁症的发病机制。
