Varma T R
Int J Gynaecol Obstet. 1984 Feb;22(1):51-8. doi: 10.1016/0020-7292(84)90104-8.
We studied 10 normal and asymptomatic patients with ovulatory cycles and measured serum sodium, potassium, FSH, LH, prolactin, estradiol, progesterone and cortisol. The findings were compared with the levels in 25 patients with ovulatory cycles with premenstrual symptoms (PMS) lasting for 7-14 days prior to the onset of menstrual flow. We found no significant difference in serum sodium and potassium levels between the asymptomatic (control) group and the PMS group, or between the follicular and luteal phases of the menstrual cycle. We found no difference in hormone levels other than an altered estrogen/progesterone ratio in the second half of the luteal phase in seven out of 12 PMS patients with severe symptoms and a higher level of cortisol in the luteal phase in six out of 12 patients with severe PMS symptoms. However, the level of serum cortisol was still within the normal range. There was no significant alteration in the levels of electrolytes or hormones during treatment with Navidrex K (cyclopenthiazide, diuretic) pyridoxine (Vitamin B-6), dydrogesterone ( Duphaston ) alone, or all the three drugs combined.
我们研究了10名排卵周期正常且无症状的患者，测量了他们血清中的钠、钾、促卵泡生成素（FSH）、促黄体生成素（LH）、催乳素、雌二醇、孕酮和皮质醇。研究结果与25名有排卵周期且在月经来潮前出现持续7 - 14天经前症状（PMS）的患者的相应水平进行了比较。我们发现无症状（对照组）组和PMS组之间，以及月经周期的卵泡期和黄体期之间，血清钠和钾水平均无显著差异。除了12名有严重症状的PMS患者中有7名在黄体期后半段雌激素/孕酮比值发生改变，以及12名有严重PMS症状的患者中有6名在黄体期皮质醇水平较高外，我们未发现激素水平存在其他差异。然而，血清皮质醇水平仍在正常范围内。单独使用Navidrex K（环戊噻嗪，利尿剂）、吡哆醇（维生素B - 6）、地屈孕酮（达芙通）或三种药物联合使用时，电解质或激素水平均无显著变化。
