Maeder Micha T, Buser Marc, Brenner Roman, Rickli Hans
1 Klinik für Kardiologie, Kantonsspital St. Gallen.
Ther Umsch. 2018 Sep;75(3):161-169. doi: 10.1024/0040-5930/a000983.
Heart failure with preserved ejection fraction (HFpEF) Abstract. Heart failure with preserved left ventricular ejection fraction (HFpEF) is a very common form of heart failure typically seen in older patients and associated with poor prognosis. Patients with HFpEF are characterized by a s small left ventricle with concentric remodeling and abnormal compliance, which under the impact of additional cardiovascular mechanisms and non-cardiac comorbidities, leads to the cardinal symptoms of dyspnea and exercise intolerance. The diagnosis of HFpEF is still under debate, and the therapeutic options are limited despite intensive research efforts. In the present review article, we provide an overview of the current understanding of the pathiohysiology of HFpEF, the current diagnostic approach, and a summary of the available evidence on treatment.
射血分数保留的心力衰竭（HFpEF）摘要。射血分数保留的左心室心力衰竭（HFpEF）是一种非常常见的心力衰竭形式，多见于老年患者，且预后较差。HFpEF患者的特征是左心室较小，伴有向心性重塑和顺应性异常，在其他心血管机制和非心脏合并症的影响下，导致呼吸困难和运动不耐受等主要症状。HFpEF的诊断仍存在争议，尽管进行了大量研究，但治疗选择仍然有限。在本综述文章中，我们概述了目前对HFpEF病理生理学的认识、当前的诊断方法以及现有治疗证据的总结。
