射血分数保留的心力衰竭：基于表型的分类对诊断和治疗至关重要。
Heart failure with preserved ejection fraction: Classification based upon phenotype is essential for diagnosis and treatment.
作者信息
Xanthopoulos Andrew, Triposkiadis Filippos, Starling Randall C
机构信息
Department of Cardiovascular Medicine, Heart and Vascular Institute, Kaufman Center for Heart Failure, Cleveland Clinic, Cleveland, OH, USA; Department of Cardiology, University General Hospital of Larissa, Larissa, Greece.
Department of Cardiology, University General Hospital of Larissa, Larissa, Greece.
出版信息
Trends Cardiovasc Med. 2018 Aug;28(6):392-400. doi: 10.1016/j.tcm.2018.01.001. Epub 2018 Jan 9.
Heart failure (HF) is classified based upon the left ventricular ejection fraction (LVEF). Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous disorder with increasing prevalence in the elderly that remains incompletely understood and inadequately treated as no therapy has shown favorable effects. In this review, we summarize the current theories regarding HFpEF pathogenesis, propose a phenotype-based classification of HFpEF, discuss prevention strategies, explain why clinical trials on HFpEF treatment have failed, and make suggestions for the future.
心力衰竭（HF）是根据左心室射血分数（LVEF）进行分类的。射血分数保留的心力衰竭（HFpEF）是一种异质性疾病，在老年人中的患病率不断上升，目前仍未被完全理解，且由于尚无治疗方法显示出良好效果，因此治疗也不充分。在本综述中，我们总结了目前关于HFpEF发病机制的理论，提出了基于表型的HFpEF分类方法，讨论了预防策略，解释了HFpEF治疗临床试验失败的原因，并对未来提出了建议。
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