Department of Infectious Diseases, The University of Queensland School of Medicine, Ochsner Clinical School, Ochsner Medical Center, 1514 Jefferson Highway, New Orleans, LA 70121, USA.
Infect Dis Clin North Am. 2018 Sep;32(3):535-550. doi: 10.1016/j.idc.2018.04.003.
Complications of antimicrobial therapy, such as multidrug-resistant organisms and Clostridium difficile, commonly affect solid-organ transplant recipients and have been associated with graft loss and mortality. Although opportunities are abundant, antimicrobial stewardship practices guiding appropriate therapy have been infrequently reported in transplant patients. A patient-centered, multidisciplinary structure, using established antimicrobial optimization principles, is needed to create nuanced approaches to protect patients and antimicrobials and improve outcomes.
抗菌治疗相关并发症，如多重耐药菌和艰难梭菌，通常会影响实体器官移植受者，并与移植物丢失和死亡相关。尽管机会很多，但指导适当治疗的抗菌药物管理实践在移植患者中鲜有报道。需要建立以患者为中心、多学科的结构，使用既定的抗菌药物优化原则，制定细致入微的方法来保护患者和抗菌药物，并改善治疗结果。
