PERFORM Center & Department of Exercise Science, Concordia University, Montreal, QC, Canada; Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal, Université de Montréal, Montreal, QC, Canada.
Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal, Université de Montréal, Montreal, QC, Canada; Faculté de Médecine Dentaire, Université de Montréal, Montreal, QC, Canada.
Int Rev Neurobiol. 2018;139:321-355. doi: 10.1016/bs.irn.2018.07.013. Epub 2018 Jul 31.
The placebo effect is a psychobiological phenomenon producing clinical benefits attributed to a wide range of neurobiological mechanisms. Independently from placebo effects, these mechanisms may also be under the influence of processes that can take place during sleep. The relationship between sleep and placebo effects has received very little attention. Three experimental studies, conducted on healthy subjects, have examined sleep changes following placebo conditioning associated with analgesic suggestions and the effects of sleep deprivation on placebo effects. A relation between rapid eye movement (REM) sleep, expectations of relief and placebo analgesia was observed in which REM sleep deprivation seems to improve placebo-induced expectations and analgesia. Moreover, analgesic expectations developed before sleep produced a reduction in cortical arousals evoked by noxious stimuli during REM sleep. In this article, we describe sleep and pain/analgesia interactions, the relationship between sleep and placebo analgesia, and finally the potential mechanisms underlying this relationship.
安慰剂效应是一种心理生物学现象，产生归因于广泛的神经生物学机制的临床益处。独立于安慰剂效应之外，这些机制也可能受到睡眠期间可能发生的过程的影响。睡眠与安慰剂效应之间的关系很少受到关注。三项在健康受试者中进行的实验研究，考察了与镇痛暗示相关的安慰剂条件作用后睡眠的变化，以及睡眠剥夺对安慰剂效应的影响。观察到快速眼动 (REM) 睡眠、缓解期望和安慰剂镇痛之间存在关系，其中 REM 睡眠剥夺似乎可以改善安慰剂引起的期望和镇痛。此外，在 REM 睡眠期间，睡眠前产生的镇痛期望降低了有害刺激引起的皮质唤醒。在本文中，我们描述了睡眠和疼痛/镇痛的相互作用，睡眠和安慰剂镇痛之间的关系，以及这种关系的潜在机制。
