Queensland University of Technology (QUT), Brisbane, 4059, Australia.
Australian Centre in Additive Biomanufacturing, Institute of Health of Biomedical Innovation, Kelvin Grove, 4059, Australia.
Adv Healthc Mater. 2018 Nov;7(21):e1800457. doi: 10.1002/adhm.201800457. Epub 2018 Aug 26.
The periodontium, consisting of gingiva, periodontal ligament, cementum, and alveolar bone, is a hierarchically organized tissue whose primary role is to provide physical and mechanical support to the teeth. Severe cases of periodontitis, an inflammatory condition initiated by an oral bacterial biofilm, can lead to significant destruction of soft and hard tissues of the periodontium and result in compromised dental function and aesthetics. Although current treatment approaches can limit the progression of the disease by controlling the inflammatory aspect, complete periodontal regeneration cannot be predictably achieved. Various tissue engineering approaches are investigated for their ability to control the critical temporo-spatial wound healing events that are essential for achieving periodontal regeneration. This paper reviews recent progress in the field of periodontal tissue engineering with an emphasis on advanced 3D multiphasic tissue engineering constructs (TECs) and provides a critical analysis of their regenerative potential and limitations. The review also elaborates on the future of periodontal tissue engineering, including scaffold customization for individual periodontal defects, TEC's functionalization strategies for imparting enhanced bioactivity, periodontal ligament fiber guidance, and the utilization of chair-side regenerative solutions that can facilitate clinical translation.
牙周组织由牙龈、牙周韧带、牙骨质和牙槽骨组成，是一种层次组织，其主要作用是为牙齿提供物理和机械支持。严重的牙周炎是一种由口腔细菌生物膜引发的炎症性疾病，如果不加以治疗，可能会导致牙周组织的软硬组织严重破坏，从而影响牙齿的功能和美观。虽然目前的治疗方法可以通过控制炎症来限制疾病的进展，但无法可预测地实现完全的牙周再生。各种组织工程方法都被研究用于控制对实现牙周再生至关重要的关键时空伤口愈合事件。本文重点介绍了先进的 3D 多相组织工程构建体（TEC），综述了牙周组织工程领域的最新进展，并对其再生潜力和局限性进行了批判性分析。本文还阐述了牙周组织工程的未来，包括针对个体牙周缺陷的支架定制、赋予增强生物活性的 TEC 功能化策略、牙周韧带纤维引导以及利用便于临床转化的椅旁再生解决方案。
