Kishibe Mari, Iwasaki Takeshi, Takahashi Ichiro, Ishida-Yamamoto Akemi
Department of Dermatology, Asahikawa Medical University, Asahikawa, Japan.
Department of Dermatology, Kitami Red Cross Hospital, Kitami, Japan.
J Cutan Pathol. 2018 Dec;45(12):923-926. doi: 10.1111/cup.13344. Epub 2018 Sep 24.
We describe a case of syringocystadenoma papilliferum (SCAP) with a unique histopathology. A 50-year-old Japanese woman presented with a pedunculated tumor in the pubic region. Histopathological examination showed that the tumor was composed of basaloid cell proliferation interconnecting from the epidermis to the dermis. Ductal structures in the tumor were lined by club-shaped columnar cells with apical snouts. Interestingly, numerous vacuolated cells with hyaline globule-like cytoplasmic inclusions were present among the columnar cells, the content of which was identified as sialomucin. Electron microscopy revealed that the vacuolated cytosol of luminal cells represented intracytoplasmic lumens with a structure similar to embryonic apocrine ducts. We assumed that this case represents a rare variant of SCAP that had differentiated toward the embryonic folliculosebaceous-apocrine unit.
我们描述了一例具有独特组织病理学表现的乳头状汗腺囊腺瘤（SCAP）。一名50岁的日本女性，其耻骨区域出现了一个带蒂肿瘤。组织病理学检查显示，该肿瘤由从表皮延伸至真皮的基底样细胞增殖构成。肿瘤中的导管结构内衬有顶端具鼻状突起的棒状柱状细胞。有趣的是，在柱状细胞之间存在大量具有透明小球样胞质内含物的空泡化细胞，其内容物被鉴定为涎黏蛋白。电子显微镜检查显示，管腔细胞的空泡化胞质溶胶代表具有类似于胚胎顶泌汗腺导管结构的胞质内管腔。我们推测该病例代表了一种向胚胎毛囊皮脂腺 - 顶泌汗腺单位分化的罕见SCAP变异型。
