Stefanov A V, Blium Ia B, Tiutiunnik V R, Veklich Iu I, Kucherenko N E
Ukr Biokhim Zh (1978). 1986 May-Jun;58(3):47-53.
To prolong the biological effect of serotonin the latter was enclosed into liposomes. The use of liposomes of phosphatidyl choline, cholesterol and dicetylphosphate in the 2:1:1 ratio permits increasing the level of serotonin incorporation inside the vesicles and reaching the slow release of serotonin out of them. It is shown by electron microscopy that sizes of liposomes enlarge due to the serotonin incorporation. When the liposomal form of serotonin is introduced to animals the amine effect on the cAMP accumulation in the liver is prolonged and intensified; an increase of the cAMP accumulation is observed in the prereplicative and replicative phases of hepatocytes synchronized by cycloheximide. The above mentioned permits a conclusion to be made that liposomes modify considerably the effect of serotonin on the cAMP system of the rat liver cells.
为了延长血清素的生物学效应，将其包裹于脂质体中。使用磷脂酰胆碱、胆固醇和磷酸二十二酯按2:1:1比例制成的脂质体，可提高血清素在囊泡内的包封水平，并实现血清素从其中的缓慢释放。电子显微镜显示，由于血清素的包封，脂质体尺寸增大。当将血清素的脂质体形式引入动物体内时，胺对肝脏中cAMP积累的作用得以延长和增强；在通过环己酰亚胺同步化的肝细胞的复制前期和复制期，观察到cAMP积累增加。上述情况使得可以得出结论，脂质体显著改变了血清素对大鼠肝细胞cAMP系统的作用。
