Chebanov S M, Torchilin V P, Berdichevskiĭ V R, Loginov A S, Smirnov V N
Biull Eksp Biol Med. 1983 Apr;95(4):110-3.
Ultrastructure of myelin-like particles and distribution of the cholesterol-digitonin reaction product in the microcirculatory vessels of mouse liver before and 1, 2, 3, 10 and 60 min after injecting liposomes containing phosphatidyl and cholesterol at a ratio of 7:2 or 2:1, the lipid concentration amounting to 0.01 mg per 1 microliter preparation. After administering the preparation via the portal or tail vein one could see a more or less marked accumulation of the cholesterol-containing granules in liver sinusoids and in Disse's space, as well as a synchronous increase in the amount of lipid drops and myelin-like structures in hepatocytes. The myelin-like particles were divided into two groups differing in the density of membrane outlay and incidence. It has been shown that hepatocytes rather than Kupffer's cells are involved into the control of the blood level of liposomal lipids.
在以7:2或2:1的比例注射含有磷脂酰胆碱和胆固醇的脂质体前以及注射后1、2、3、10和60分钟，小鼠肝脏微循环血管中类髓鞘样颗粒的超微结构及胆固醇-洋地黄皂苷反应产物的分布，脂质浓度为每1微升制剂0.01毫克。经门静脉或尾静脉给药后，可观察到肝血窦和狄氏间隙中含胆固醇颗粒或多或少有明显积聚，同时肝细胞中脂滴和类髓鞘样结构的数量同步增加。类髓鞘样颗粒分为两组，其膜支出密度和发生率不同。结果表明，参与脂质体脂质血液水平调控的是肝细胞而非库普弗细胞。
