[Ultrastructure of the myelin-like particles in the liver of mice administered liposomes with various levels of cholesterol and phosphatidylcholine].

Ultrastructure of myelin-like particles and distribution of the cholesterol-digitonin reaction product in the microcirculatory vessels of mouse liver before and 1, 2, 3, 10 and 60 min after injecting liposomes containing phosphatidyl and cholesterol at a ratio of 7:2 or 2:1, the lipid concentration amounting to 0.01 mg per 1 microliter preparation. After administering the preparation via the portal or tail vein one could see a more or less marked accumulation of the cholesterol-containing granules in liver sinusoids and in Disse's space, as well as a synchronous increase in the amount of lipid drops and myelin-like structures in hepatocytes. The myelin-like particles were divided into two groups differing in the density of membrane outlay and incidence. It has been shown that hepatocytes rather than Kupffer's cells are involved into the control of the blood level of liposomal lipids.