Andrianova I P, Zuevskiĭ V V, Rabovskiĭ A B, Tsybul'skaia M V, Nikitin Iu S
Vopr Med Khim. 1986 May-Jun;32(3):55-7.
Industrial silicates, silochromes, proved to be effective sorbents of cholesterol lipoprotein complexes in blood in vitro. Silochrome SH-1.5 with a diameter of pores of 180-200 nm and a capacity of 12-14 mg of cholesterol per 1 g of the sorbent exhibited the best efficiency in isolation of the complexes. At the same time, maximal unspecific binding of blood plasma proteins was observed in the systems with silochrome SH-3 with a diameter of pores of 60 nm. By use of silochrome SH-1.5 for plasmosorption the content of cholesterol was decreased from 3,600 mg/l down to 2,150 mg/l, i.e. by 40%, in blood plasma of a rabbit with experimental hypercholesterolemia.
工业硅酸盐、硅铬合物在体外被证明是血液中胆固醇脂蛋白复合物的有效吸附剂。孔径为180 - 200纳米、每1克吸附剂胆固醇吸附量为12 - 14毫克的硅铬合物SH - 1.5在分离这些复合物时表现出最佳效率。同时，在孔径为60纳米的硅铬合物SH - 3体系中观察到血浆蛋白的最大非特异性结合。使用硅铬合物SH - 1.5进行血浆吸附后，实验性高胆固醇血症兔子血浆中的胆固醇含量从3600毫克/升降至2150毫克/升，即降低了40%。
