.的乙醇叶提取物的抗菌和毒理学评价
Antimicrobial and toxicological evaluation of ethanol leaf extract of .
作者信息
Essien Augustine Dick, Akuodor Godwin Christian, Ajoku Gloria Ahunna, Megwas Anthony Uchenna, Anele Donatus Onyebuchi, Ezeunala Mercy Nwakaego, Okezie Alozie Ogwuegbu
机构信息
Department of Pharmacology, College of Medical Sciences, University of Calabar, Calabar, Nigeria.
Department of Pharmacology and Therapeutics, Faculty of Medicine, Ebonyi State University, Abakaliki, Nigeria.
出版信息
Interdiscip Toxicol. 2017 Dec;10(4):163-167. doi: 10.1515/intox-2017-0023. Epub 2018 Mar 1.
The leaves of are used ethnomedically across Africa for the treatment of different diseases its antimicrobial activity as well as toxicological profile were evaluated. Antimicrobial activity against clinical strains of , , , , and were compared with Gentamycin. Toxicological investigation was determined by administering 100 mg/kg, 200 mg/kg and 400 mg/kg of the ethanol leaf extract to male Wistar rats for 21 days with distilled water as control. Hematological and biochemical parameters as well as the vital organs were examined. The ethanol extract inhibited the growth of , , , , and to varying extents. The LD in rats was greater than 5000 mg/kg. Toxicological evaluation of the extract did not produce any significant effect on hematological and biochemical parameters and vital organs in rats. ethanol leaf extract did not demonstrate antimicrobial activity against selected microorganisms. Neither did it show any non-toxic effect on the parameters investigated in rats. Thus the extract can be considered safe when administered orally.
在非洲各地，人们在民族医学中使用[植物名称]的叶子来治疗各种疾病，并对其抗菌活性和毒理学特征进行了评估。将其对[临床菌株名称]的临床菌株的抗菌活性与庆大霉素进行了比较。通过给雄性Wistar大鼠分别灌胃100 mg/kg、200 mg/kg和400 mg/kg的乙醇叶提取物，持续21天，以蒸馏水作为对照，进行毒理学研究。检测了血液学和生化参数以及重要器官。乙醇提取物对[临床菌株名称]的生长有不同程度的抑制作用。大鼠的半数致死剂量大于5000 mg/kg。提取物的毒理学评估对大鼠的血液学和生化参数以及重要器官没有产生任何显著影响。[植物名称]乙醇叶提取物对所选微生物没有显示出抗菌活性。对大鼠所研究的参数也没有显示出任何无毒作用。因此，口服该提取物可被认为是安全的。
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