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一名患有IgA血管炎的儿童出现伴有组织嗜酸性粒细胞增多的水疱性皮疹。

Blistering eruptions with tissue eosinophilia in a child with IgA vasculitis.

作者信息

Watanabe Toru, Tsukano Shinya

机构信息

Department of Pediatrics Niigata City General Hospital Niigata City Japan.

出版信息

Clin Case Rep. 2018 Jun 4;6(8):1422-1425. doi: 10.1002/ccr3.1631. eCollection 2018 Aug.

DOI:10.1002/ccr3.1631
PMID:30147875
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6099028/
Abstract

We present a child with bullous IgA vasculitis. Because skin biopsy showed epidermal vesicles with neutrophil infiltration and leukocytoclastic vasculitis in all layers of the dermis, with IgA deposits and tissue eosinophilia, extensive dermal infiltration of neutrophils may have led to both blistering eruptions and tissue eosinophilia in our patient.

摘要

我们报告一名患有大疱性IgA血管炎的儿童。由于皮肤活检显示表皮水疱伴有中性粒细胞浸润以及真皮各层的白细胞破碎性血管炎,伴有IgA沉积和组织嗜酸性粒细胞增多,中性粒细胞在真皮的广泛浸润可能导致了我们患者出现水疱性皮疹和组织嗜酸性粒细胞增多。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e896/6099028/28d85b1db448/CCR3-6-1422-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e896/6099028/0f9bebcc64da/CCR3-6-1422-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e896/6099028/48fa3b356b46/CCR3-6-1422-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e896/6099028/28d85b1db448/CCR3-6-1422-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e896/6099028/0f9bebcc64da/CCR3-6-1422-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e896/6099028/48fa3b356b46/CCR3-6-1422-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e896/6099028/28d85b1db448/CCR3-6-1422-g003.jpg

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本文引用的文献

1
New insights in the pathogenesis of immunoglobulin A vasculitis (Henoch-Schönlein purpura).免疫球蛋白 A 血管炎(过敏性紫癜)发病机制的新见解。
Autoimmun Rev. 2017 Dec;16(12):1246-1253. doi: 10.1016/j.autrev.2017.10.009. Epub 2017 Oct 14.
2
Blistering eruptions in childhood Henoch-Schönlein syndrome: systematic review of the literature.儿童过敏性紫癜的水疱性皮疹:文献系统评价
Eur J Pediatr. 2017 Apr;176(4):487-492. doi: 10.1007/s00431-017-2858-3. Epub 2017 Feb 4.
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Bullous skin lesions in an adult male: a diagnostic dilemma.
成年男性的大疱性皮肤病变:诊断难题。
Am J Case Rep. 2015 Apr 10;16:215-9. doi: 10.12659/AJCR.893218.
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Self-limiting recurrent bullous Henoch-Schonlein purpura with lupus anticoagulant.伴有狼疮抗凝物的自限性复发性大疱性过敏性紫癜
BMJ Case Rep. 2015 Jan 20;2015:bcr2014205436. doi: 10.1136/bcr-2014-205436.
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Two distinct leukotriene B4 receptors, BLT1 and BLT2.两种不同的白三烯B4受体,即BLT1和BLT2。
J Biochem. 2015 Feb;157(2):65-71. doi: 10.1093/jb/mvu078. Epub 2014 Dec 4.
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Diagnosis and management of cutaneous vasculitis in children.儿童皮肤血管炎的诊断与治疗。
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Histopathology and correlates of systemic disease in adult Henoch-Schönlein purpura: a retrospective study of microscopic and clinical findings in 68 patients at Mayo Clinic.成人过敏性紫癜的组织病理学和系统性疾病相关性:梅奥诊所 68 例患者的微观和临床发现的回顾性研究。
J Am Acad Dermatol. 2013 Mar;68(3):420-424.e3. doi: 10.1016/j.jaad.2012.08.011. Epub 2012 Sep 6.
8
Vancomycin-induced Henoch-Schönlein purpura: a case report.万古霉素诱发的过敏性紫癜:一例报告
J Med Case Rep. 2012 Apr 10;6:106. doi: 10.1186/1752-1947-6-106.
9
The histological assessment of cutaneous vasculitis.皮肤血管炎的组织学评估。
Histopathology. 2010 Jan;56(1):3-23. doi: 10.1111/j.1365-2559.2009.03443.x.
10
Inverse temporal changes of lipoxin A4 and leukotrienes in children with Henoch-Schönlein purpura.过敏性紫癜患儿中脂氧素A4和白三烯的反向时间变化
Prostaglandins Leukot Essent Fatty Acids. 2009 Apr;80(4):177-83. doi: 10.1016/j.plefa.2009.01.008. Epub 2009 Mar 4.