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一名患有神经纤维瘤病的患者出现复发性胃胃肠道间质瘤。

Recurrent Gastric Gastrointestinal Stromal Tumor in a Patient with Neurofibromatosis.

作者信息

Al Momani Laith A, Abughanimeh Omar, Shipley Lindsey C, Phemister Jennifer, Swenson James, Young Mark

机构信息

Department of Internal Medicine, East Tennessee State University, Johnson City, USA.

Department of Internal Medicine, University of Missouri Kansas City School of Medicine, Kansas City, USA.

出版信息

Cureus. 2018 Jun 21;10(6):e2854. doi: 10.7759/cureus.2854.

DOI:10.7759/cureus.2854
PMID:30148007
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6104896/
Abstract

Neurofibromatosis type 1 is an autosomal dominant neurocutaneous disorder characterized by a mutation of the neurofibromin 1 (NF1) gene, resulting in increased susceptibility for multiple tumors, namely, gastrointestinal stromal tumors (GISTs)-the most common types of mesenchymal neoplasms in the gastrointestinal tract. Despite these tumors' predilection for the stomach, it seems to be the least likely part of the gastrointestinal (GI) tract to be affected in cases of neurofibromatosis. Herein, we report a case of a 61-year-old male patient with known neurofibromatosis, who presented with acute blood loss anemia due to a recurrent gastric GIST, requiring partial gastrectomy due to its size and multiple recurrences.

摘要

1型神经纤维瘤病是一种常染色体显性神经皮肤疾病，其特征为神经纤维瘤蛋白1（NF1）基因发生突变，导致对多种肿瘤的易感性增加，即胃肠道间质瘤（GIST）——胃肠道中最常见的间叶性肿瘤类型。尽管这些肿瘤好发于胃部，但在神经纤维瘤病病例中，胃肠道似乎是最不容易受影响的部位。在此，我们报告一例61岁男性患者，已知患有神经纤维瘤病，因复发性胃GIST导致急性失血性贫血，因其大小和多次复发而需要进行部分胃切除术。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a6d/6104896/30b83c29e5e1/cureus-0010-00000002854-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a6d/6104896/9a4e225adc6a/cureus-0010-00000002854-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a6d/6104896/b6c5d8ef95bd/cureus-0010-00000002854-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a6d/6104896/a09ca482dcf9/cureus-0010-00000002854-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a6d/6104896/5fe70eab8ec2/cureus-0010-00000002854-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a6d/6104896/30b83c29e5e1/cureus-0010-00000002854-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a6d/6104896/9a4e225adc6a/cureus-0010-00000002854-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a6d/6104896/b6c5d8ef95bd/cureus-0010-00000002854-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a6d/6104896/a09ca482dcf9/cureus-0010-00000002854-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a6d/6104896/5fe70eab8ec2/cureus-0010-00000002854-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a6d/6104896/30b83c29e5e1/cureus-0010-00000002854-i05.jpg

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Oncol Lett. 2016 Jul;12(1):637-643. doi: 10.3892/ol.2016.4670. Epub 2016 Jun 1.
3
Global epidemiology of gastrointestinal stromal tumours (GIST): A systematic review of population-based cohort studies.
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World J Clin Cases. 2019 Dec 26;7(24):4398-4406. doi: 10.12998/wjcc.v7.i24.4398.
4
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4
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