药物输送系统在生长因子控释中的应用治疗神经系统损伤。
Application of drug delivery systems for the controlled delivery of growth factors to treat nervous system injury.
机构信息
a Department of Neurosurgery , Fudan University Huashan Hospital and National Key Laboratory of Medical Neurobiology, the Institutes of Brain Science, Shanghai Medical College, Fudan University , Shanghai , China.
b Department of Neurology , Guizhou Provincial People's Hospital , Guiyang , China.
出版信息
Organogenesis. 2018;14(3):123-128. doi: 10.1080/15476278.2018.1491183. Epub 2018 Aug 27.
Nervous system injury represent the most common injury and was unique clinical challenge. Using of growth factors (GFs) for the treatment of nervous system injury showed effectiveness in halting its process. However, simple application of GFs could not achieve high efficacy because of its rapid diffusion into body fluids and lost from the lesion site. The drug delivery systems (DDSs) construction used to deliver GFs were investigated so that they could surmount its rapid diffusion and retain at the injury site. This study summarizes commonly used DDSs for sustained release of GFs that provide neuroprotection or restoration effects for nervous system injury.
神经系统损伤是最常见的损伤，也是独特的临床挑战。生长因子（GFs）用于治疗神经系统损伤的效果表明其在阻止损伤过程中是有效的。然而，由于 GFs 迅速扩散到体液中并从损伤部位丢失，单纯应用 GFs 并不能达到高疗效。因此，人们研究了用于输送 GFs 的药物输送系统（DDS）的构建，以便克服其快速扩散并在损伤部位保留。本研究总结了常用于持续释放 GFs 的 DDS，这些 DDS 为神经系统损伤提供了神经保护或修复作用。
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