Christchurch Regenerative Medicine and Tissue Engineering (CReaTE) Group, Department of Orthopaedic Surgery and Musculoskeletal Medicine, University of Otago Christchurch, Christchurch, New Zealand.
Adv Exp Med Biol. 2018;1078:245-269. doi: 10.1007/978-981-13-0950-2_13.
Growth factors (GFs) are often a key component in tissue engineering and regenerative medicine approaches. In order to fully exploit the therapeutic potential of GFs, GF delivery vehicles have to meet a number of key design criteria such as providing localized delivery and mimicking the dynamic native GF expression levels and patterns. The use of biomaterials as delivery systems is the most successful strategy for controlled delivery and has been translated into different commercially available systems. However, the risk of side effects remains an issue, which is mainly attributed to insufficient control over the release profile. This book chapter reviews the current strategies, chemistries, materials and delivery vehicles employed to overcome the current limitations associated with GF therapies.
生长因子 (GFs) 通常是组织工程和再生医学方法的关键组成部分。为了充分发挥 GFs 的治疗潜力，GF 递送载体必须满足许多关键设计标准，例如提供局部递送并模拟动态天然 GF 表达水平和模式。生物材料作为递送系统的使用是控制递送的最成功策略，并已转化为不同的商业可用系统。然而，副作用的风险仍然是一个问题，这主要归因于对释放谱的控制不足。本章回顾了目前用于克服与 GF 治疗相关的当前限制的策略、化学物质、材料和递送载体。
