Arany Istvan, Taylor Mary, Fülöp Tibor, Dixit Mehul
Int J Clin Pharmacol Ther. 2018 Nov;56(11):501-506. doi: 10.5414/CP203302.
With the increasing popularity of E-cigarettes, chronic exposure to nicotine (NIC) is emerging as a novel risk factor for the kidney. NIC increases oxidative stress in the kidneys, which impairs the viability and function of renal tubular and endothelial cells, alters renal hemodynamics, and compromises overall kidney function. Moreover, long-term NIC exposure increases the risk of development and progression of chronic kidney diseases and may escalate the impact of coexisting morbidities such as obesity-associated renal disease, hypertension, renal transplant status, or the toxicity of various anticancer agents. In this review, we summarize experimental findings describing increased renal risk of chronic NIC exposure and explore therapeutic interventions to alleviate adverse effects of NIC. .
随着电子烟越来越受欢迎，长期接触尼古丁正成为肾脏的一种新的危险因素。尼古丁会增加肾脏中的氧化应激，损害肾小管和内皮细胞的活力与功能，改变肾脏血流动力学，并损害整体肾功能。此外，长期接触尼古丁会增加慢性肾病发生和进展的风险，并可能加剧肥胖相关肾病、高血压、肾移植状态或各种抗癌药物毒性等并存疾病的影响。在本综述中，我们总结了描述长期接触尼古丁会增加肾脏风险的实验结果，并探索减轻尼古丁不良影响的治疗干预措施。
