Division of Nephrology, Department of Internal Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, 158, Paryong-ro, Masanhoewon-gu, Changwon, 51353, Republic of Korea.
Sci Rep. 2021 Jan 27;11(1):2381. doi: 10.1038/s41598-021-81777-5.
The association between alcohol consumption and kidney function is intriguing, but study results are mixed and controversial. We examined the association of alcohol consumption with the overall change in kidney function over 12 years. We analyzed data from a population-based cohort that was part of the Korean Genome and Epidemiology Study. Primary exposure was total alcohol intake (non-drinkers, 0 to < 10 g/day, 10 to < 30 g/day, and ≥ 30 g/day). Main outcome was decline in kidney function over 12 years. Our study included 5729 participants (mean [SD] age, 51 [8] years; 46% males). Compared to non-drinkers, higher alcohol intake groups had lesser reduction in estimated glomerular filtration rate (eGFR) over 12 years; fully adjusted beta coefficients and 95% confidence intervals were 0.45 (- 0.27, 1.18), 1.87 (0.88, 2.87), and 3.08 (1.93, 4.24) for participants with alcohol intake of < 10, 10 to < 30, and ≥ 30 g/day, respectively. However, this association was attenuated among women, smoker, and age ≥ 60 year. Compared with not drinking, more frequent alcohol consumption and binge drinking were associated with lesser reduction in eGFR. Our findings suggest that alcohol consumption may have a favorable effect on kidney function among the general population.
饮酒与肾功能之间的关系令人关注，但研究结果存在差异和争议。我们研究了饮酒与 12 年内肾功能整体变化的关系。我们分析了韩国基因组与流行病学研究人群的基于人群的队列数据。主要暴露因素为酒精总摄入量（非饮酒者、<10g/天、10-<30g/天和≥30g/天）。主要结局为 12 年内肾功能下降。我们的研究纳入了 5729 名参与者（平均[标准差]年龄为 51[8]岁，46%为男性）。与不饮酒者相比，饮酒量较高者 12 年内估算肾小球滤过率（eGFR）下降幅度较小；经完全调整的β系数及其 95%置信区间分别为 0.45（-0.27，1.18）、1.87（0.88，2.87）和 3.08（1.93，4.24），对应的饮酒量分别为<10g、10-<30g 和≥30g。然而，这种相关性在女性、吸烟者和年龄≥60 岁的人群中减弱。与不饮酒相比，饮酒频率更高和 binge drinking 与 eGFR 下降幅度较小有关。我们的研究结果表明，在一般人群中，饮酒可能对肾功能有有益影响。
