Prado-Ribeiro A-C, Santos-Silva A-R, Faria K-M, Silva W-G, Simonato L-E, Moutinho K, Brandão T-B
Instituto do Câncer do Estado de São Paulo [ICESP], Faculdade de Medicina da Universidade de São Paulo, Dental Oncology Service, São Paulo, Brazil, Avenida Doutor Arnaldo, 251, São Paulo - SP, Brasil, CEP: 01246-000,
Med Oral Patol Oral Cir Bucal. 2018 Sep 1;23(5):e518-e523. doi: 10.4317/medoral.22470.
Acute toxicity is usually defined as adverse changes occurring immediately or a short time after the start of oncological treatment.
Cross-sectional retrospective study performed with head and neck cancer patients who underwent radiotherapy from 2013 to 2016.
Ten (1.2%) patients developed SOMs during radiotherapy, most (80%) of which were men with a mean age of 59.5 years at diagnosis. SOMs mainly affected the floor of the mouth (60%) between the fourth and the sixth weeks of radiation therapy. All lesions were asymptomatic and spontaneously ruptured approximately 9 days after diagnosis.
Although rare, SOMs may be regarded as an acute oral toxicity of head and neck radiotherapy.
急性毒性通常定义为肿瘤治疗开始后立即或短时间内出现的不良变化。
对2013年至2016年接受放疗的头颈癌患者进行横断面回顾性研究。
10例（1.2%）患者在放疗期间出现口腔黏膜下纤维化，其中大多数（80%）为男性，诊断时平均年龄为59.5岁。口腔黏膜下纤维化主要在放疗的第四至六周影响口腔底部（60%）。所有病变均无症状，诊断后约9天自发破裂。
尽管罕见，但口腔黏膜下纤维化可被视为头颈放疗的一种急性口腔毒性。
