Dept. of Medical Oncology, S. Croce General Hospital, Cuneo, Italy.
Dept. of Medical Oncology, Translational Oncology Lab, S. Croce General Hospital, Cuneo, Italy.
Oral Oncol. 2012 Oct;48(10):1051-1057. doi: 10.1016/j.oraloncology.2012.05.001. Epub 2012 Jun 2.
The purpose of this study is to retrospectively analyze acute toxicity encountered in young and old patients treated with chemo-radiation or bio-radiation at the S. Croce General Hospital between 1997 and 2008, in daily clinical practice.
Three hundred and seventeen patients were allocated into two groups according to age (cut-off 65 years). The two groups were compared in terms of treatment related toxicities, treatment activity and efficacy. Epidermal Growth factor receptor (EGFr), Human papillomavirus (HPV) and p53 status were also considered.
As expected, overall survival was significantly worse in elderly patients (p=0.005), but response rate, including complete response rate, was similar between the two age groups, as were most of the side effects analyzed. However, infections (p=0.011) and in particular pneumonias (p=0.002) were significantly more represented in elderly patients.
Elderly patients treated with chemo-radiation or bio-radiation in our centre had a higher risk of infection and in particular, pneumonia. These data suggest a more careful follow-up, but age alone does not justify their exclusion from treatment.
本研究旨在回顾性分析 1997 年至 2008 年期间在 S. Croce 综合医院接受放化疗或生物放化疗的年轻和老年患者在日常临床实践中遇到的急性毒性。
根据年龄（65 岁为界）将 317 名患者分为两组。比较两组患者的治疗相关毒性、治疗活性和疗效。还考虑了表皮生长因子受体 (EGFr)、人乳头瘤病毒 (HPV) 和 p53 状态。
正如预期的那样，老年患者的总生存率明显较差（p=0.005），但两组之间的反应率（包括完全反应率）相似，分析的大多数副作用也是如此。然而，感染（p=0.011），尤其是肺炎（p=0.002）在老年患者中更为常见。
在我们中心接受放化疗或生物放化疗的老年患者感染风险更高，特别是肺炎。这些数据表明需要更仔细的随访，但仅年龄并不能证明将其排除在治疗之外是合理的。
