Dawson-Hughes B, Seligson F H, Hughes V A
Am J Clin Nutr. 1986 Jul;44(1):83-8. doi: 10.1093/ajcn/44.1.83.
We measured the effect of calcium carbonate and hydroxyapatite on whole-body retention of zinc-65 in 11 and iron-59 in 13 healthy, postmenopausal women. In a single-blind, controlled, crossover study, each subject, on three occasions, ingested a standard test meal supplemented with iron-59 or zinc-65 and capsules containing placebo or 500 mg elemental calcium as calcium carbonate or hydroxyapatite. Whole-body countings were performed prior to, 30 min after, and 2 wk after each meal. Mean (SEM) zinc retention was 18.1 +/- 1.0% with placebo (control) and did not vary significantly with calcium carbonate (110.0 +/- 8.6% of control) or hydroxyapatite (106.0 +/- 7.9% of control). Iron retention, 6.3 +/- 2.0% with placebo, was significantly reduced with both calcium carbonate (43.3 +/- 8.8% of control, p = 0.002) and hydroxyapatite (45.9 +/- 10.0% of control, p = 0.003). Iron absorption may be significantly reduced when calcium supplements are taken with meals.
我们测量了碳酸钙和羟基磷灰石对11名健康绝经后女性体内65锌全身潴留以及13名健康绝经后女性体内59铁全身潴留的影响。在一项单盲、对照、交叉研究中，每位受试者分三次摄入一份补充了59铁或65锌的标准测试餐以及含有安慰剂或500毫克元素钙（以碳酸钙或羟基磷灰石形式）的胶囊。每餐之前、餐后30分钟以及餐后2周进行全身计数。服用安慰剂（对照组）时，锌的平均（标准误）潴留率为18.1±1.0%，服用碳酸钙（对照组的110.0±8.6%）或羟基磷灰石（对照组的106.0±7.9%）时，锌潴留率无显著变化。服用安慰剂时，铁的潴留率为6.3±2.0%，服用碳酸钙（对照组的43.3±8.8%，p = 0.002）和羟基磷灰石（对照组的45.9±10.0%，p = 0.003）时，铁潴留率均显著降低。用餐时服用钙补充剂可能会显著降低铁的吸收。
