Valberg L S, Flanagan P R, Chamberlain M J
Am J Clin Nutr. 1984 Sep;40(3):536-41. doi: 10.1093/ajcn/40.3.536.
Zinc absorption as measured by body retention of [65Zn]zinc chloride or a turkey test meal extrinsically labeled with 65Zn was determined in human subjects by whole body counting after 7 days. Average 65Zn absorption from zinc chloride in persons with a high iron-absorbing capacity was similar to persons with a low capacity to absorb iron. Inorganic iron, 920 mumol (51 mg), or HB iron, 480 mumol (26 mg), inhibited 65Zn absorption from 92 mumol (6 mg) of zinc chloride. When 610 mumol of iron (34 mg) was added to a turkey test meal containing 61 mumol of zinc (4 mg), 65Zn absorption was not inhibited. Tin, 306 mumol (36 mg), given with zinc chloride or turkey test meals (61 mumol, 4 mg, of Zn) significantly reduced 65Zn absorption. Copper, 79 mumol (5 mg), had no significant effect on the 65Zn absorption from 7.9 mumol (0.5 mg) of zinc chloride. In summary, the capacity to absorb iron did not influence 65Zn absorption, but both inorganic iron and heme-iron inhibited 65Zn absorption from zinc chloride. Inorganic iron had no effect, however, on 65Zn absorption from the turkey test meal. Tin in a large dose also inhibited 65Zn absorption from both zinc chloride and the turkey test meal.
通过全身计数法在人体受试者中测定了锌的吸收情况，具体方法是在7天后测量[65Zn]氯化锌或用65Zn外在标记的火鸡测试餐在体内的保留量。高铁吸收能力者从氯化锌中吸收65Zn的平均量与低铁吸收能力者相似。无机铁920微摩尔（51毫克）或血红蛋白铁480微摩尔（26毫克）抑制了从92微摩尔（6毫克）氯化锌中吸收65Zn。当向含有61微摩尔锌（4毫克）的火鸡测试餐中添加610微摩尔铁（34毫克）时，65Zn的吸收未受抑制。与氯化锌或火鸡测试餐（61微摩尔，4毫克锌）一起给予的306微摩尔（36毫克）锡显著降低了65Zn的吸收。79微摩尔（5毫克）铜对从7.9微摩尔（0.5毫克）氯化锌中吸收65Zn没有显著影响。总之，铁的吸收能力不影响65Zn的吸收，但无机铁和血红素铁均抑制从氯化锌中吸收65Zn。然而，无机铁对从火鸡测试餐中吸收65Zn没有影响。大剂量的锡也抑制从氯化锌和火鸡测试餐中吸收65Zn。
