类黄酮可降低辐射诱导的大鼠主动脉血管紧张素转换酶活性的增加。
Flavonoids decrease the radiation-induced increase in the activity of the angiotensin-converting enzyme in rat aorta.
机构信息
Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, 142290 Russia.
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, 142290, Russia.
出版信息
Eur J Pharmacol. 2018 Oct 15;837:33-37. doi: 10.1016/j.ejphar.2018.08.029. Epub 2018 Aug 25.
The basic factor of cardiovascular diseases is atherosclerosis, which is due largely to an increase in the activity of the angiotensin-converting enzyme (ACE) in vessels. Flavonoids diminish the risk of cardiovascular diseases and the flavonoid taxifolin normalizes the activity of ACE. We examined the efficiency of seven flavonoids in preventing an increase in ACE activity in aorta of rats exposed to ionizing radiation. It was shown that the activity of flavones and flavonols decreases with an increase in the number of OH groups in the A and B rings, respectively. The reduction in the activity of flavonoids within the classes correlates with a decrease in their lipophilicity. Flavanonols (taxifolin) are more active than flavonols, and flavonols are more active than flavones.
心血管疾病的基本因素是动脉粥样硬化，这主要是由于血管中血管紧张素转换酶（ACE）的活性增加所致。类黄酮可降低心血管疾病的风险，而类黄酮紫杉叶素可使 ACE 的活性正常化。我们研究了七种类黄酮在预防电离辐射暴露大鼠主动脉中 ACE 活性增加方面的功效。结果表明，随着 A 和 B 环中 OH 基团数量的增加，黄酮和黄酮醇的活性分别降低。类黄酮类化合物活性的降低与疏水性的降低相关。黄烷醇（紫杉叶素）比黄酮醇更活跃，黄酮醇比黄酮更活跃。
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