Peterson D O, Drummond J C, Todd M M
Anesthesiology. 1986 Jul;65(1):35-40. doi: 10.1097/00000542-198607000-00006.
Median nerve somatosensory evoked potentials (SSEPs) were recorded in 21 healthy subjects anesthetized with halothane, isoflurane, or enflurane (with and without nitrous oxide) for abdominal or pelvic surgery. Recordings were made prior to induction, then at 0.5 MAC increments of each volatile agent with 60% N2O up to 1.5 MAC, and, finally, at 1.5 MAC without N2O. All three volatile anesthetics produced dose-related reductions in the amplitude and increases in the latency of the cortical component of the SSEP. These changes were most pronounced with enflurane and least with halothane. At 1.5 MAC of each volatile agent, cortical latency decreased and amplitude increased when nitrous oxide was discontinued. The results suggest that in neurologically intact patients, end-tidal concentrations of 1.0 MAC halothane and 0.5 MAC enflurane or isoflurane (each in 60% N2O) can be compatible with effective SSEP monitoring. Volatile anesthetic concentrations consistent with satisfactory somatosensory-evoked potential recording may be greater if N2O is not employed.
对21名接受腹部或盆腔手术、用氟烷、异氟烷或安氟醚（有或没有氧化亚氮）麻醉的健康受试者记录正中神经体感诱发电位（SSEP）。在诱导前进行记录，然后在每种挥发性麻醉剂以0.5MAC递增并伴有60%氧化亚氮的情况下直至1.5MAC进行记录，最后在1.5MAC且无氧化亚氮的情况下进行记录。所有三种挥发性麻醉剂均使SSEP皮层成分的波幅出现剂量相关的降低以及潜伏期延长。这些变化在安氟醚时最为明显，在氟烷时最不明显。在每种挥发性麻醉剂的1.5MAC时，停用氧化亚氮后皮层潜伏期缩短，波幅增大。结果表明，在神经功能正常的患者中，呼气末浓度为1.0MAC的氟烷以及0.5MAC的安氟醚或异氟烷（均在60%氧化亚氮中）可与有效的SSEP监测相容。如果不使用氧化亚氮，与令人满意的体感诱发电位记录相一致的挥发性麻醉剂浓度可能更高。
