通过胎粪污染羊水出生的婴儿进行洗胃预防早期喂养不耐受：一项随机对照试验。

Gastric lavage in babies born through meconium stained amniotic fluid in prevention of early feed intolerance: A randomized controlled trial.

作者信息

Yadav S K, Venkatnarayan K, Adhikari K M, Sinha R, Mathai S S

机构信息

Nepalese Army Institute of Health Sciences, Shree Birendra Hospital, Kathmandu, Nepal.

Department of Pediatrics, Command Hospital, Pune, India.

出版信息

J Neonatal Perinatal Med. 2018;11(4):393-397. doi: 10.3233/NPM-17154.

DOI:10.3233/NPM-17154

PMID:30149474

Abstract

OBJECTIVE

To evaluate the efficacy of gastric lavage (GL) in preventing feed intolerance in babies born through Meconium stained amniotic fluid (MSAF).

STUDY DESIGN

In this randomized trial conducted at a tertiary care hospital, neonates born of MSAF after 34 weeks period of gestation requiring routine care were randomly allocated to GL with 10 ml/kg of normal saline. The control group did not receive GL. The subjects were monitored for first 24 hours in predefined time epochs. The primary outcome was incidence of feed intolerance which was defined as vomiting or abdominal distension more than 2 cm from baseline measure. Babies were also monitored for potential adverse events due to GL and total duration of hospital stay.

RESULTS

Baseline parameters were comparable. The incidence of feed intolerance was not significant in the GL group [4.6% vs 9.2%; RR 0.92 (0.29-3)]. There were no adverse events secondary to GL. The duration of hospital stay was comparable between groups.

CONCLUSION

GL in neonates born of MSAF does not reduce feed intolerance.

摘要

目的

评估洗胃（GL）对预防胎粪污染羊水（MSAF）出生婴儿喂养不耐受的疗效。

研究设计

在一家三级护理医院进行的这项随机试验中，妊娠34周后因MSAF出生且需要常规护理的新生儿被随机分配接受10 ml/kg生理盐水洗胃。对照组未接受洗胃。在预定的时间段内对受试者进行24小时监测。主要结局是喂养不耐受的发生率，定义为呕吐或腹胀超过基线测量值2 cm。还对婴儿因洗胃导致的潜在不良事件和住院总时长进行了监测。