Israel H L, Gushue G F, Park C H
Ann N Y Acad Sci. 1986;465:455-62. doi: 10.1111/j.1749-6632.1986.tb18522.x.
Gallium-67 scans have been widely employed in patients with sarcoidosis as a means of indicating alveolitis and the need for corticosteroid therapy. Observation of 32 patients followed 3 or more years after gallium scans showed no correlation between findings and later course: of 10 patients with pulmonary uptake, 7 recovered with minor residuals; of 18 patients with mediastinal of extrathoracic uptake, 10 had persistent or progressive disease; of 4 patients with negative initial scans, 2 had later progression. The value of gallium-67 scans as an aid to diagnosis was studied in 40 patients with extrapulmonary sarcoidosis. In 12 patients, abnormal lacrimal, nodal, or pulmonary uptake aided in selection of biopsy sites. Gallium-67 scans and serum ACE levels were compared in 97 patients as indices of clinical activity. Abnormal gallium-67 uptake was observed in 96.3% of the tests in active disease, and ACE level elevation occurred in 56.3%. In 24 patients with inactive or recovered disease, abnormal gallium-67 uptake occurred in 62.5% and ACE level elevation in 37.5%. Gallium-67 scans have a limited but valuable role in the diagnosis and management of sarcoidosis.
镓-67扫描已广泛应用于结节病患者，作为指示肺泡炎及是否需要糖皮质激素治疗的一种手段。对32例患者在镓扫描后随访3年或更长时间的观察显示，扫描结果与疾病后期进程之间无相关性：在10例肺部有摄取的患者中，7例康复，仅留轻微后遗症；在18例纵隔或胸外有摄取的患者中，10例有持续性或进行性疾病；在4例初始扫描为阴性的患者中，2例后来病情进展。对40例肺外结节病患者研究了镓-67扫描对诊断的辅助价值。在12例患者中，泪腺、淋巴结或肺部的异常摄取有助于选择活检部位。对97例患者比较了镓-67扫描和血清血管紧张素转换酶（ACE）水平作为临床活动指标的情况。在活动性疾病患者中，96.3%的检测观察到镓-67摄取异常，而ACE水平升高的占56.3%。在24例非活动性或已康复疾病患者中，镓-67摄取异常的占62.5%，ACE水平升高的占37.5%。镓-67扫描在结节病的诊断和管理中作用有限但有价值。
