Gupta R G, Bekerman C, Sicilian L, Oparil S, Pinsky S M, Szidon J P
Radiology. 1982 Sep;144(4):895-9. doi: 10.1148/radiology.144.4.6287521.
Gallium 67 citrate scans and serum angiotensin converting enzyme (ACE) levels were obtained in 54 patients with sarcoidosis and analyzed in relation to clinical manifestations. 67Ga scans were abnormal in 97% of patients with clinically active disease (n = 30) and in 71% of patients with inactive disease (n = 24). Serum ACE levels were abnormally high (2 standard deviations above the control mean) in 73% of patients with clinically active disease and in 54% of patients with inactive disease. Serum ACE levels correlated significantly with 67Ga uptake score (r =.436; p less than .005). The frequency of abnormal 67Ga scans and elevated serum ACE levels suggests that inflammatory activity with little or no clinical expression is common in sarcoidosis. Abnormal 67Ga scans were highly sensitive (97%) but had poor specificity (29%) to clinical disease activity. The accuracy of negative prediction of clinical activity by normal scans (87%) was better than the accuracy of positive prediction of clinical activity by abnormal scans (63%). 67Ga scans can be used to support the clinical identification of inactive sarcoidosis.
对54例结节病患者进行了枸橼酸镓67扫描及血清血管紧张素转换酶（ACE）水平检测，并分析其与临床表现的关系。在临床活动期患者（n = 30）中，97%的患者67Ga扫描异常；在非活动期患者（n = 24）中，71%的患者67Ga扫描异常。临床活动期患者中73%血清ACE水平异常升高（高于对照均值2个标准差），非活动期患者中54%血清ACE水平异常升高。血清ACE水平与67Ga摄取评分显著相关（r = 0.436；p < 0.005）。67Ga扫描异常及血清ACE水平升高的频率表明，结节病中炎症活动很少或没有临床表现很常见。67Ga扫描异常对临床疾病活动度高度敏感（97%），但特异性较差（29%）。正常扫描对临床活动度阴性预测的准确性（87%）优于异常扫描对临床活动度阳性预测的准确性（63%）。67Ga扫描可用于辅助临床识别非活动期结节病。
