Niu Xingyu
Department of Oral Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People's Republic of China.
Laryngoscope. 2019 May;129(5):1137-1140. doi: 10.1002/lary.27474. Epub 2018 Aug 27.
The goal of this study was to analyze the results of clinical treatment of sarcomatoid carcinoma in the parotid gland by reviewing 30 years of experience.
Thirty-five patients were enrolled in this study. The Kaplan-Meier methods were used to calculate the recurrence-free survival (RFS) and disease-specific survival (DSS) rates. The Cox model was used to determine the independent risk factor.
Mean age at presentation was 57.8 years, and most of the patients were staged as tumor (T)3 or T4. Perineural invasion was noted in 15 (42.9%) patients. Fifteen (42.9%) patients received neck dissection due to clinically suspicious nodes. Of those, three patients had pathologically positive nodes. Recurrence was noted in 14 patients; the most common pattern of treatment failure was local recurrence, and only 40% of the patients could receive salvaged surgical treatment. Disease-specific death was noted in 10 patients. The 5-year RFS and DSS rates were 67.3% and 65.7%, respectively. In a multivariate analysis, only the factor of perineural invasion was independently correlated with death.
Parotid sarcomatoid carcinoma carries a poor prognosis, and perineural invasion was the most important predictive factor.
2b Laryngoscope, 129:1137-1140, 2019.
本研究旨在通过回顾30年的经验来分析腮腺肉瘤样癌的临床治疗结果。
本研究纳入了35例患者。采用Kaplan-Meier方法计算无复发生存率（RFS）和疾病特异性生存率（DSS）。使用Cox模型确定独立危险因素。
患者的平均就诊年龄为57.8岁，大多数患者分期为肿瘤（T）3或T4。15例（42.9%）患者出现神经侵犯。15例（42.9%）患者因临床可疑淋巴结而接受颈部清扫术。其中，3例患者病理检查发现淋巴结阳性。14例患者出现复发；最常见的治疗失败模式是局部复发，只有40%的患者能够接受挽救性手术治疗。10例患者出现疾病特异性死亡。5年RFS和DSS率分别为67.3%和65.7%。多因素分析显示，只有神经侵犯因素与死亡独立相关。
腮腺肉瘤样癌预后较差，神经侵犯是最重要的预测因素。
2b 《喉镜》，2019年，第129卷，第1137 - 1140页
