Department of Oral Medicine, The First Affiliated hospital of Zhengzhou University, Zhengzhou, People's Republic of China.
Department of Head Neck and Thyroid, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, China.
BMC Cancer. 2019 May 3;19(1):417. doi: 10.1186/s12885-019-5637-x.
Prognostic factors for parotid mucoepidermoid carcinoma (MEC) usually include disease grade, tumor stage, node stage, perineural invasion, and lymphovascular invasion. But the role of intraparotid nodes (IPNs) remains unclear, therefore, the study aimed to analyze the significance of IPNs in predicting recurrence in parotid MEC.
One hundred and ninety patients were included for analysis finally. Data regarding demography, pathological characteristics, IPN metastasis, TNM stage, follow up was collected and evaluated. The recurrence-free survival (RFS) was the main study endpoint.
A total of 47 (24.7%) patients had IPN metastasis, and the IPN metastasis was significantly related to tumor stage, pathologic N stage, lymph-vascular invasion, perineural invasion, and disease grade. Recurrence occurred in 34 (17.9%) patients. For patients without IPN metastasis, the 10-year RFS rate was 88%, for patients with IPN metastasis, the 10-year RFS rate was 54%, the difference was significant (p < 0.001). Further Cox model analysis confirmed the independence of IPN metastasis in predicting the prognosis.
The IPN metastasis is relatively common in parotid MEC, it is significantly related to tumor stage and disease grade, IPN metastasis means worse recurrence-free survival.
腮腺黏液表皮样癌（MEC）的预后因素通常包括疾病分级、肿瘤分期、淋巴结分期、神经周围侵犯和血管淋巴管侵犯。然而，腮腺内淋巴结（IPN）的作用仍不清楚，因此，本研究旨在分析 IPN 在预测腮腺 MEC 复发中的意义。
最终纳入 190 例患者进行分析。收集并评估了人口统计学、病理特征、IPN 转移、TNM 分期、随访等数据。无复发生存（RFS）是主要研究终点。
共有 47 例（24.7%）患者存在 IPN 转移，IPN 转移与肿瘤分期、病理 N 分期、淋巴血管侵犯、神经周围侵犯和疾病分级显著相关。34 例（17.9%）患者出现复发。对于无 IPN 转移的患者，10 年 RFS 率为 88%，而有 IPN 转移的患者 10 年 RFS 率为 54%，差异有统计学意义（p<0.001）。进一步的 Cox 模型分析证实了 IPN 转移对预后的独立预测作用。
腮腺 MEC 中 IPN 转移较为常见，与肿瘤分期和疾病分级显著相关，IPN 转移提示无复发生存更差。
