Koret School of Veterinary Medicine, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, Israel.
Koret School of Veterinary Medicine, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, Israel.
Semin Cell Dev Biol. 2019 Aug;92:97-104. doi: 10.1016/j.semcdb.2018.08.010. Epub 2018 Aug 29.
Specification of primordial germ cells (PGCs) in all vertebrates takes place in extragonadal sites. This requires migration of PGCs through embryonic tissues towards the genital ridges by both passive and active types of migration. Commonly, colonization in the genital ridges follows migration of the PGCs along the thin tissue of the dorsal mesentery. Here we review the anatomy of the dorsal mesentery, the role it plays in migration of PGCs, and the interactions of PGCs with different cell types, extracellular matrix and signaling pathways that are all essential for attraction and orientation of PGCs along the dorsal mesentery towards the gonad anlage.
所有脊椎动物的原始生殖细胞 (PGC) 的特化发生在性腺外部位。这需要 PGC 通过被动和主动两种类型的迁移穿过胚胎组织向生殖嵴迁移。通常，PGC 沿着背肠系膜的薄组织迁移，随后在生殖嵴中定植。在这里，我们回顾了背肠系膜的解剖结构，它在 PGC 迁移中的作用，以及 PGC 与不同细胞类型、细胞外基质和信号通路的相互作用，这些对于 PGC 沿着背肠系膜向性腺原基的吸引和定向都是必不可少的。
