Servicio de Dermatología, Hospital Universitari Vall d'Hebron, Barcelona, España.
Servicio de Dermatología, Hospital Universitari Vall d'Hebron, Barcelona, España.
Med Clin (Barc). 2018 Dec 14;151(11):444-449. doi: 10.1016/j.medcli.2018.06.024. Epub 2018 Aug 25.
Lupus panniculitis (LP) is a rare variant of chronic cutaneous lupus erythematosus, which diagnosis requires clinicopathological correlation, especially in those patients without any other manifestation of lupus erythematosus (LE). According to the phase when the biopsy is performed, histological findings can be non-specific. Few series have been published to date. Hence, we report our own experience in the diagnosis and management of this disease.
We conducted a retrospective descriptive clinicopathological study of 12 patients diagnosed in our centre.
All the patients had painful and recurrent plaques and/or nodules, with a predilection for proximal extremities, face and scalp. Histopathologic examination showed mostly lobular panniculitis and lymphoplasmacytic infiltrate. For the diagnosis, we also considered the coexistence of other clinical manifestations of LE as well as the expression of CD123 by immunohistochemistry. In 3 patients, LP was the first manifestation of LE.
The diagnosis of LP can be difficult. The presence of other clinical and/or histological manifestations of LE along with immunohistochemistry techniques could help in the differential diagnosis with other panniculitis.
狼疮性脂膜炎（LP）是一种罕见的慢性皮肤型红斑狼疮变异型，其诊断需要临床病理相关性，特别是在那些没有任何其他红斑狼疮（LE）表现的患者中。根据活检进行的阶段，组织学发现可能是非特异性的。迄今为止，已经发表了少数几篇系列文章。因此，我们报告了我们在诊断和治疗这种疾病方面的经验。
我们对在我们中心诊断的 12 名患者进行了回顾性描述性临床病理研究。
所有患者均有疼痛性和复发性斑块和/或结节，好发于近端肢体、面部和头皮。组织病理学检查显示主要为小叶性脂膜炎和淋巴浆细胞浸润。为了诊断，我们还考虑了 LE 的其他临床表现以及免疫组织化学检查中 CD123 的表达。在 3 例患者中，LP 是 LE 的首发表现。
LP 的诊断可能具有挑战性。LE 的其他临床和/或组织学表现以及免疫组织化学技术的存在有助于与其他脂膜炎进行鉴别诊断。
