干血斑用于抗高血压药物定量分析
The Use of Dried Blood Spots for the Quantification of Antihypertensive Drugs.
作者信息
Chernonosov Alexander
机构信息
Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of Russian Academy of Sciences, Academician Lavrentiev Avenue 8, Novosibirsk 630090, Russia.
出版信息
Int J Anal Chem. 2018 Aug 1;2018:3235072. doi: 10.1155/2018/3235072. eCollection 2018.
Hypertension or high blood pressure is a harbinger of cardiovascular diseases. There are several classes of drugs used to treat hypertension. This review discusses the use of dried blood spots (DBSs) for the quantification by mass spectrometry (MS), tandem mass spectrometry (MS/MS), or, in some cases, by fluorescence detection methods the following antihypertensive medications: angiotensin-converting enzyme inhibitors (ramipril, ramiprilat, captopril, and lisinopril); angiotensin II receptor antagonists (valsartan, irbesartan, losartan, and losartan carboxylic acid); calcium channel blockers (verapamil, amlodipine, nifedipine, pregabalin, and diltiazem); blockers (guanfacine, doxazosin, and prazosin); blockers (propranolol, bisoprolol, atenolol, and metoprolol); endothelin receptor antagonists (bosentan and ambrisentan); and statins (simvastatin, atorvastatin, and rosuvastatin).
高血压是心血管疾病的先兆。有几类药物用于治疗高血压。本综述讨论了使用干血斑（DBS）通过质谱（MS）、串联质谱（MS/MS）或在某些情况下通过荧光检测方法对以下抗高血压药物进行定量分析：血管紧张素转换酶抑制剂（雷米普利、雷米普利拉、卡托普利和赖诺普利）；血管紧张素II受体拮抗剂（缬沙坦、厄贝沙坦、氯沙坦和氯沙坦羧酸）；钙通道阻滞剂（维拉帕米、氨氯地平、硝苯地平、普瑞巴林和地尔硫卓）；α受体阻滞剂（胍法辛、多沙唑嗪和哌唑嗪）；β受体阻滞剂（普萘洛尔、比索洛尔、阿替洛尔和美托洛尔）；内皮素受体拮抗剂（波生坦和安立生坦）；以及他汀类药物（辛伐他汀、阿托伐他汀和瑞舒伐他汀）。
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