Central Laboratory, Seventh People's Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China.
Department of Drug Preparation, Hospital of TCM and Hui Nationality Medicine, Ningxia Medical University, Wuzhong, China.
Curr Pharm Des. 2018;24(24):2774-2781. doi: 10.2174/1381612824666180829103355.
All forms of chronic kidney disease (CKD) eventually lead to renal fibrosis irrespective of its origin. It is generally characterized by an excessive accumulation and deposition of extracellular matrix (ECM) and to date, no ideal treatment has been established. Bian-Zheng-Lun-Zhi (syndrome differentiation and treatment), a classic feature of traditional Chinese Medicine (TCM), is a unique method used to diagnose and treat the pathology of a disease. Zheng (syndrome) is used to demonstrate the nature of a disease completely in an extensive and specific manner. Chinese herbal formulas are determined according to TCM theory and this review highlights these formulas and suggests a possible mechanism for their use in the treatment of renal fibrosis.
所有形式的慢性肾脏病（CKD）最终都会导致肾脏纤维化，无论其起源如何。其通常的特征是细胞外基质（ECM）的过度积累和沉积，迄今为止，尚未建立理想的治疗方法。辨证论治（中医辨证论治）是中医的一个经典特色，是一种独特的诊断和治疗疾病病理的方法。证（症候）用于全面而具体地展示疾病的本质。中药方剂是根据中医理论确定的，本综述强调了这些方剂，并提出了它们在治疗肾纤维化中的可能作用机制。
