Huang Shu-Ping, Zhang Ze-Chao, Chen Yu, Shang Chang-Jie, Zhu Min, Li Wei-Hong
Department of Traditional Chinese Medicine Surgery, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning, China.
Department of Yao College of Medicine and Graduate School, Guangxi University of Chinese Medicine, Nanning, China.
Medicine (Baltimore). 2025 Jul 11;104(28):e42957. doi: 10.1097/MD.0000000000042957.
The phosphatidylinositol-3-kinase (PI3K)/protein kinase B (AKT) signaling pathway plays a crucial role in the regulation of fibrosis, a pathological process characterized by excessive deposition of extracellular matrix components leading to tissue scarring and dysfunction. Traditional Chinese medicine (TCM) has been increasingly recognized for its potential therapeutic effects in fibrosis by targeting various signaling pathways, including the PI3K/AKT pathway. This review aims to summarize the recent advancements in TCM interventions targeting the PI3K/AKT signaling pathway for the regulation of fibrotic diseases. Recent studies have explored the potential of TCM in the prevention and treatment of fibrotic diseases, particularly through the modulation of the PI3K/AKT signaling pathway. To gather information on TCM and the PI3K/AKT pathway, an extensive search was conducted across various scientific databases, such as Google Scholar, Web of Science, Scifinder, Baidu Scholar and PubMed. TCM has demonstrated unique potential in managing fibrotic diseases through the modulation of the PI3K/AKT signaling pathway. About 37 types of TCM monomers, 68 species of extracts and related compounds, and 50 types of TCM formulas. It discusses their treatment effects on fibrosis in various organs by regulating the PI3K/AKT pathway. The current advancements in TCM interventions targeting the PI3K/AKT pathway offer novel perspectives and strategies for the management of fibrotic diseases. TCM has shown positive effects in treating fibrotic diseases.
磷脂酰肌醇-3-激酶（PI3K）/蛋白激酶B（AKT）信号通路在纤维化调节中起关键作用，纤维化是一种以细胞外基质成分过度沉积导致组织瘢痕形成和功能障碍为特征的病理过程。中药因其通过靶向包括PI3K/AKT通路在内的各种信号通路在纤维化治疗中的潜在疗效而日益受到认可。本综述旨在总结中药干预PI3K/AKT信号通路调节纤维化疾病的最新进展。最近的研究探索了中药在预防和治疗纤维化疾病方面的潜力，特别是通过调节PI3K/AKT信号通路。为了收集有关中药和PI3K/AKT通路的信息，我们在多个科学数据库中进行了广泛搜索，如谷歌学术、科学网、Scifinder、百度学术和PubMed。中药已证明通过调节PI3K/AKT信号通路在管理纤维化疾病方面具有独特潜力。约37种中药单体、68种提取物及相关化合物以及50种中药方剂。它讨论了它们通过调节PI3K/AKT通路对各器官纤维化的治疗作用。目前针对PI3K/AKT通路的中药干预进展为纤维化疾病的管理提供了新的视角和策略。中药在治疗纤维化疾病方面已显示出积极效果。
