Liang Yan, Zhang Zhiyu, Li Jie, Yang Zaixing
Department of Laboratory Medicine, Changzheng Hospital, Naval Medical University, Shanghai, China.
Health Management Center, Changzheng Hospital, Naval Medical University, Shanghai, China.
Clin Rheumatol. 2025 Mar;44(3):1237-1243. doi: 10.1007/s10067-025-07327-w. Epub 2025 Jan 23.
The aim of this study was to determine serum I-309 levels in primary Sjögren's syndrome (pSS) patients, as well as the association with disease phenotype, systemic activity, and T helper cell-related cytokines. A total of 58 pSS patients and 30 healthy controls (HC) were enrolled in this study. The concentrations of serum I-309, interleukin-4 (IL-4), IL-6, IL-9, IL-13, IL-17, IL-22, IL-23, tumor-necrosis factor-α (TNF-α), interferon-γ (IFN-γ), IFN-α, and IFN-β were measured with multiplex immunoassay. The relationships between I-309 and various clinical and laboratory variables were analyzed. The serum concentrations of I-309 were significantly increased (median, IQR, 14.24, 10.99--20.35, pg/ml) in pSS patients compared with HC (median, IQR, 8.27, 6.74--9.62, pg/ml) (P < 0.001). Serum I-309 is increased in pSS, and may be associated with systemic inflammation, Th1-, Th17,- and Th9 cells, type Key Points • Serum I-309 levels are increased in pSS patients. • Increased I-309 may be associated with systemic rather than local manifestations in pSS. • Increased I-309 may be associated with Th1, Th17 and Th9 other than Th2 in pSS. • There may be close relationships between I-309 and type land type II IFNs in pSS.
本研究旨在测定原发性干燥综合征（pSS）患者的血清I-309水平，以及其与疾病表型、全身活动和辅助性T细胞相关细胞因子的关联。本研究共纳入了58例pSS患者和30名健康对照（HC）。采用多重免疫测定法检测血清I-309、白细胞介素-4（IL-4）、IL-6、IL-9、IL-13、IL-17、IL-22、IL-23、肿瘤坏死因子-α（TNF-α）、干扰素-γ（IFN-γ）、IFN-α和IFN-β的浓度。分析I-309与各种临床和实验室变量之间的关系。与HC（中位数，四分位间距，8.27，6.74--9.62，pg/ml）相比，pSS患者血清I-309浓度显著升高（中位数，四分位间距，14.24，10.99--20.35，pg/ml）（P < 0.001）。pSS患者血清I-309升高，可能与全身炎症、Th1、Th17和Th9细胞有关，类型要点• pSS患者血清I-309水平升高。• I-309升高可能与pSS的全身而非局部表现有关。• I-309升高可能与pSS中的Th1、Th17和Th9而非Th2有关。• pSS中I-309与I型和II型干扰素之间可能存在密切关系。
