• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

窦卵泡计数能否调节阿伯丁安格斯和尼洛里小母牛牛输卵管的基因表达？

Can the antral follicular count modulate the gene expression of bovine oviducts in Aberdeen Angus and Nelore heifers?

机构信息

Departament of Pharmacology, Institute of Biosciences, Universidade Estadual Paulista (UNESP), Botucatu, São Paulo, Brazil.

Departament of Morphology, Institute of Biosciences, Universidade Estadual Paulista (UNESP), Botucatu, São Paulo, Brazil.

出版信息

PLoS One. 2018 Aug 29;13(8):e0202017. doi: 10.1371/journal.pone.0202017. eCollection 2018.

DOI:10.1371/journal.pone.0202017
PMID:30157205
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6114296/
Abstract

The number of visible ovarian antral follicles (antral follicle count-AFC) is repeatable in bovine individuals, but highly variable between animals, and with differences between Bos taurus and Bos indicus breeds. Several studies have tried to determine the correlation between AFC and increased fertility in cattle. While the impacts of AFC on embryo production, hormonal levels, and pregnancy rates have been described, the molecular effects of AFC on bovine oviducts have not yet been investigated. Here, the aim was to investigate the impact of breeds, such as Aberdeen Angus and Nelore heifer with high or low AFC, on abundance of transcripts and protein related to oviductal transport, sperm reservoir formation, monospermy control, and gamete interaction in the oviducts. In summary, the ovulation side was the major factor that affected transcript abundance on bovine oviducts. However, a discreet effect among AFC and cattle breeds was also observed. Based on this, we concluded and reinforced here that differential microenvironments between ipsilateral and contralateral oviducts have a major effect on modulating the transcripts related to oviductal transport, sperm reservoir formation, monospermy control, and gamete interaction. However, we cannot exclude that there is minimal effect of AFC or breed on regulation of some genes (such as AGTR1, ACE1, FUCA1, and VEGFA) in bovine oviducts.

摘要

可见卵巢窦卵泡数（窦卵泡计数-AFC）在牛个体中是可重复的，但在动物之间高度可变，并且在瘤牛和印度瘤牛品种之间存在差异。已有多项研究试图确定 AFC 与牛的生育力增加之间的相关性。虽然已经描述了 AFC 对胚胎生产、激素水平和妊娠率的影响，但 AFC 对牛输卵管的分子影响尚未得到研究。在这里，目的是研究具有高或低 AFC 的阿伯丁安格斯和尼洛里小母牛等品种对输卵管运输、精子储备形成、单精受精控制和配子相互作用相关的转录物和蛋白质丰度的影响。总之，排卵侧是影响牛输卵管转录物丰度的主要因素。然而，也观察到 AFC 和牛品种之间存在离散效应。基于此，我们在这里得出结论并强调，输卵管同侧和对侧之间的不同微环境对调节与输卵管运输、精子储备形成、单精受精控制和配子相互作用相关的转录物有重大影响。然而，我们不能排除 AFC 或品种对牛输卵管中某些基因（如 AGTR1、ACE1、FUCA1 和 VEGFA）的调控有最小的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd2f/6114296/6c9ae8b5c896/pone.0202017.g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd2f/6114296/0d9e69198cfc/pone.0202017.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd2f/6114296/092ea6affba0/pone.0202017.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd2f/6114296/5472591a5354/pone.0202017.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd2f/6114296/c736506fffd4/pone.0202017.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd2f/6114296/5dfb933eed9a/pone.0202017.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd2f/6114296/de48495406b5/pone.0202017.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd2f/6114296/7dfbea617bce/pone.0202017.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd2f/6114296/91532f85584d/pone.0202017.g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd2f/6114296/ec2f28ba3141/pone.0202017.g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd2f/6114296/6c9ae8b5c896/pone.0202017.g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd2f/6114296/0d9e69198cfc/pone.0202017.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd2f/6114296/092ea6affba0/pone.0202017.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd2f/6114296/5472591a5354/pone.0202017.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd2f/6114296/c736506fffd4/pone.0202017.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd2f/6114296/5dfb933eed9a/pone.0202017.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd2f/6114296/de48495406b5/pone.0202017.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd2f/6114296/7dfbea617bce/pone.0202017.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd2f/6114296/91532f85584d/pone.0202017.g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd2f/6114296/ec2f28ba3141/pone.0202017.g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd2f/6114296/6c9ae8b5c896/pone.0202017.g010.jpg

相似文献

1
Can the antral follicular count modulate the gene expression of bovine oviducts in Aberdeen Angus and Nelore heifers?窦卵泡计数能否调节阿伯丁安格斯和尼洛里小母牛牛输卵管的基因表达？
PLoS One. 2018 Aug 29;13(8):e0202017. doi: 10.1371/journal.pone.0202017. eCollection 2018.
2
The correlation between the number of antral follicles and ovarian reserves (preantral follicles) in purebred Bos indicus and Bos taurus cows.纯种印度瘤牛和普通牛中窦状卵泡数量与卵巢储备（窦前卵泡）之间的相关性。
Anim Reprod Sci. 2014 Dec 30;151(3-4):119-25. doi: 10.1016/j.anireprosci.2014.10.016. Epub 2014 Oct 24.
3
Expression of androgen-producing enzyme genes and testosterone concentration in Angus and Nellore heifers with high and low ovarian follicle count.卵巢卵泡数量高和低的安格斯和内洛尔小母牛中雄激素生成酶基因的表达及睾酮浓度
Theriogenology. 2016 Jul 15;86(2):523-7. doi: 10.1016/j.theriogenology.2016.02.001. Epub 2016 Feb 10.
4
Comparison of antral and preantral ovarian follicle populations between Bos indicus and Bos indicus-taurus cows with high or low antral follicles counts.印度瘤牛与印度瘤牛-普通牛杂交母牛中，具有高或低窦状卵泡计数的窦状卵泡和窦前卵泡群体的比较。
Reprod Domest Anim. 2014 Feb;49(1):48-51. doi: 10.1111/rda.12222. Epub 2013 Aug 2.
5
Correlation between phenotype, genotype and antral follicle population in beef heifers.肉牛小母牛的表型、基因型与窦卵泡数量之间的相关性。
Theriogenology. 2017 Mar 15;91:21-26. doi: 10.1016/j.theriogenology.2016.12.025. Epub 2016 Dec 28.
6
Follicle populations and gene expression profiles of Nelore and Angus heifers with low and high ovarian follicle counts.具有低和高卵巢卵泡数的尼洛丽牛和安格斯小母牛的卵泡群体和基因表达谱。
Mol Reprod Dev. 2019 Feb;86(2):197-208. doi: 10.1002/mrd.23095. Epub 2018 Dec 18.
7
Antral follicle populations and embryo production--in vitro and in vivo--of Bos indicus-taurus donors from weaning to yearling ages.断奶至一岁龄印度瘤牛-黄牛供体的窦卵泡数量及胚胎生产——体内和体外研究
Reprod Domest Anim. 2014 Apr;49(2):228-32. doi: 10.1111/rda.12255. Epub 2014 Jan 23.
8
Plasma antimullerian hormone as a predictor of ovarian antral follicular population in Bos indicus (Nelore) and Bos taurus (Holstein) heifers.血浆抗苗勒管激素作为印度瘤牛（Nellore）和荷斯坦奶牛小母牛卵巢窦状卵泡数量的预测指标。
Reprod Domest Anim. 2014 Jun;49(3):448-52. doi: 10.1111/rda.12304. Epub 2014 Apr 2.
9
High numbers of antral follicles are positively associated with in vitro embryo production but not the conception rate for FTAI in Nelore cattle.在Nellore牛中，大量的窦状卵泡与体外胚胎生产呈正相关，但与定时人工授精的受孕率无关。
Anim Reprod Sci. 2016 Feb;165:17-21. doi: 10.1016/j.anireprosci.2015.11.024. Epub 2015 Dec 3.
10
Ovulation rate, antral follicle count, and circulating anti-Müllerian hormone in Trio allele carriers, a novel high fecundity bovine genotype.携带Trio等位基因的牛的排卵率、窦卵泡计数及循环抗缪勒氏管激素，一种新型的高繁殖力牛基因型。
Theriogenology. 2017 Oct 1;101:81-90. doi: 10.1016/j.theriogenology.2017.05.026. Epub 2017 Jun 3.

引用本文的文献

1
Effect of estrous cycle phases on gene expression in bovine oviduct epithelial cells.发情周期阶段对牛输卵管上皮细胞基因表达的影响。
Vet World. 2022 Jul;15(7):1665-1675. doi: 10.14202/vetworld.2022.1665-1675. Epub 2022 Jul 14.
2
Association analysis of loci implied in "buffering" epistasis.“缓冲”上位性相关位点的关联分析。
J Anim Sci. 2020 Mar 1;98(3). doi: 10.1093/jas/skaa045.

本文引用的文献

1
Beef heifers with diminished numbers of antral follicles have decreased uterine protein concentrations.具有窦状卵泡数量减少的小母牛子宫蛋白质浓度降低。
Anim Reprod Sci. 2017 Apr;179:1-9. doi: 10.1016/j.anireprosci.2017.01.004. Epub 2017 Jan 12.
2
Expression of androgen-producing enzyme genes and testosterone concentration in Angus and Nellore heifers with high and low ovarian follicle count.卵巢卵泡数量高和低的安格斯和内洛尔小母牛中雄激素生成酶基因的表达及睾酮浓度
Theriogenology. 2016 Jul 15;86(2):523-7. doi: 10.1016/j.theriogenology.2016.02.001. Epub 2016 Feb 10.
3
The relationship between antral follicle count in a bovine ovary and developmental competence of in vitro-grown oocytes derived from early antral follicles.
牛卵巢中窦状卵泡计数与来源于早期窦状卵泡的体外培养卵母细胞发育能力之间的关系。
Biomed Res. 2016;37(1):63-71. doi: 10.2220/biomedres.37.63.
4
Size of the Ovulatory Follicle Dictates Spatial Differences in the Oviductal Transcriptome in Cattle.排卵卵泡大小决定牛输卵管转录组的空间差异。
PLoS One. 2015 Dec 23;10(12):e0145321. doi: 10.1371/journal.pone.0145321. eCollection 2015.
5
Mammalian sperm interactions with the female reproductive tract.哺乳动物精子与雌性生殖道的相互作用。
Cell Tissue Res. 2016 Jan;363(1):185-194. doi: 10.1007/s00441-015-2244-2. Epub 2015 Jul 17.
6
α-L-fucosidase enhances capacitation-associated events in porcine spermatozoa.α-L-岩藻糖苷酶增强猪精子的获能相关事件。
Vet J. 2015 Jan;203(1):109-14. doi: 10.1016/j.tvjl.2014.11.006. Epub 2014 Nov 15.
7
Viable and morphologically normal boar spermatozoa alter the expression of heat-shock protein genes in oviductal epithelial cells during co-culture in vitro.在体外共培养过程中，有活力且形态正常的公猪精子会改变输卵管上皮细胞中热休克蛋白基因的表达。
Mol Reprod Dev. 2014 Sep;81(9):805-19. doi: 10.1002/mrd.22350. Epub 2014 Aug 4.
8
Ciliary beating plane and wave propagation in the bovine oviduct.牛输卵管中的纤毛摆动平面和波传播
Cells Tissues Organs. 2013;198(6):457-69. doi: 10.1159/000360155. Epub 2014 Apr 2.
9
Plasma antimullerian hormone as a predictor of ovarian antral follicular population in Bos indicus (Nelore) and Bos taurus (Holstein) heifers.血浆抗苗勒管激素作为印度瘤牛（Nellore）和荷斯坦奶牛小母牛卵巢窦状卵泡数量的预测指标。
Reprod Domest Anim. 2014 Jun;49(3):448-52. doi: 10.1111/rda.12304. Epub 2014 Apr 2.
10
The morphology of the oviduct of virgin heifers in relation to the estrous cycle.未孕小母牛输卵管形态与发情周期的关系
J Morphol. 1950 Jan;86(1):1-23. doi: 10.1002/jmor.1050860102.