Lulé Dorothée, Hörner Katharina, Vazquez Cynthia, Aho-Özhan Helena, Keller Jürgen, Gorges Martin, Uttner Ingo, Ludolph Albert C
Department of Neurology, University of Ulm, Ulm, Germany.
Front Neurosci. 2018 Aug 15;12:517. doi: 10.3389/fnins.2018.00517. eCollection 2018.
In many neurological conditions, there is a combination of decline in physical function and cognitive abilities. For far advanced stages of physical disability where speaking and hand motor abilities are severely impaired, there is a lack of standardized approach to screen for cognitive profile. = 40 healthy subjects were included in the study. For proof of principle, = 6 ALS patients were additionally measured. For cognitive screening, we used the Edinburgh cognitive and behavioral ALS screen (ECAS) in the standard paper-and-pencil version. Additionally, we adapted the ECAS to a brain-machine interface (BMI) control module to screen for cognition in severely advanced patients. There was a high congruency between BMI version and the paper-and-pencil version of the ECAS. Sensitivity and specificity of the ECAS-BMI were mostly high whereas stress and weariness for the patient were low. We hereby present evidence that adaptation of a standardized neuropsychological test for BMI control is feasible. BMI driven neuropsychological test provides congruent results compared to standardized tests with a good specificity and sensitivity but low patient load.
在许多神经系统疾病中，身体功能和认知能力都会出现下降。对于身体残疾极为严重的晚期阶段，即言语和手部运动能力严重受损的情况，缺乏用于筛查认知状况的标准化方法。该研究纳入了40名健康受试者。为了验证原理，另外对6例肌萎缩侧索硬化症（ALS）患者进行了测量。对于认知筛查，我们使用了标准纸笔版的爱丁堡认知与行为ALS筛查量表（ECAS）。此外，我们将ECAS改编为一个脑机接口（BMI）控制模块，以筛查病情极为严重的患者的认知情况。BMI版与纸笔版的ECAS之间具有高度一致性。ECAS-BMI的敏感性和特异性大多较高，而患者的压力和疲劳程度较低。我们在此提供证据表明，将标准化神经心理测试改编用于BMI控制是可行的。与标准化测试相比，BMI驱动的神经心理测试能提供一致的结果，具有良好的特异性和敏感性，且患者负担较小。
