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半醌循环。细胞色素bc型复合物中电子传递和质子转运的一种假说。

The semiquinone cycle. A hypothesis of electron transfer and proton translocation in cytochrome bc-type complexes.

作者信息

Wikström M, Krab K

出版信息

J Bioenerg Biomembr. 1986 Jun;18(3):181-93. doi: 10.1007/BF00743463.

DOI:10.1007/BF00743463
PMID:3015895
Abstract

The Q cycle and the b cycle are the main current models of action of the cytochrome bc-type complexes of mitochondria, bacteria, and chloroplasts. Both are based on the concept, proposed in 1972, of two sequential one-electron oxidations of (ubi)quinol along two discrete pathways which operate at different redox potentials, and with bound semiubiquinone as an intermediate. The models differ in two respects, viz. in the pathway of electron transfer and the principle of linkage of electron transfer to proton translocation. In this article we outline a new model, called the semiquinone or, simply, SQ cycle, which is based on the electron transfer principles of the b cycle but which incorporates the Q cycle concept of direct coupling between electron transfer and proton translocation through action of ubiquinone.

摘要

Q循环和b循环是目前关于线粒体、细菌和叶绿体中细胞色素bc型复合物作用的主要模型。两者都基于1972年提出的概念,即(泛)醌醇沿着两条在不同氧化还原电位下运行的离散途径进行两个连续的单电子氧化,并以结合的半醌作为中间体。这两个模型在两个方面有所不同,即电子传递途径以及电子传递与质子转运的偶联原理。在本文中,我们概述了一种新模型,称为半醌模型或简称为SQ循环,它基于b循环的电子传递原理,但通过泛醌的作用纳入了电子传递与质子转运直接偶联的Q循环概念。

相似文献

1
The semiquinone cycle. A hypothesis of electron transfer and proton translocation in cytochrome bc-type complexes.半醌循环。细胞色素bc型复合物中电子传递和质子转运的一种假说。
J Bioenerg Biomembr. 1986 Jun;18(3):181-93. doi: 10.1007/BF00743463.
2
Electron and proton transfers through quinones and cytochrome bc complexes.电子和质子通过醌类和细胞色素bc复合物的转移。
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3
A perspective on Q-cycles.关于Q循环的观点。
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A Q-cycle mechanism for the cyclic electron-transfer chain of Rhodopseudomonas sphaeroides.球形红假单胞菌循环电子传递链的Q循环机制。
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The oxidation-reduction kinetics of cytochromes b, c1 and c in initially fully reduced mitochondrial membranes are in agreement with the Q-cycle hypothesis.细胞色素b、c1和c在最初完全还原的线粒体膜中的氧化还原动力学与Q循环假说相符。
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Effect of substituents of the benzoquinone ring on electron-transfer activities of ubiquinone derivatives.苯醌环取代基对泛醌衍生物电子转移活性的影响。
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The pathway of electron transfer in the dimeric QH2: cytochrome c oxidoreductase.二聚体QH2:细胞色素c氧化还原酶中的电子传递途径。
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Radical-pair energetics and decay mechanisms in reaction centers containing anthraquinones, naphthoquinones or benzoquinones in place of ubiquinone.在反应中心中,用蒽醌、萘醌或苯醌取代泛醌后的自由基对能量学及衰变机制。
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Thermodynamic and kinetic considerations of Q-cycle mechanisms and the oxidant-induced reduction of cytochromes b.Q循环机制的热力学和动力学考量以及氧化剂诱导的细胞色素b还原
J Bioenerg Biomembr. 1985 Feb;17(1):51-64. doi: 10.1007/BF00744988.

引用本文的文献

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The Q cycle of cytochrome bc complexes: a structure perspective.细胞色素bc复合物的Q循环:结构视角
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Mechanism of electron transfer in the cytochrome b/f complex of algae: evidence for a semiquinone cycle.

本文引用的文献

1
Control of electron transfer in the cytochrome system of mitochondria by pH, transmembrane pH gradient and electrical potential. The cytochromes b-c segment.通过pH值、跨膜pH梯度和电势对线粒体细胞色素系统中电子转移的控制。细胞色素b-c段。
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A generalised model for the equilibration of quinone pools with their biological donors and acceptors in membrane-bound electron transfer chains.膜结合电子传递链中醌池与其生物供体和受体平衡的通用模型。
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1H-NMR study of the location and motion of ubiquinones in perdeuterated phosphatidylcholine bilayers.
藻类细胞色素b/f复合体中电子转移的机制:半醌循环的证据
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Two substitutions at the same position in the mitochondrial cytochrome b gene of S. cerevisiae induce a mitochondrial myxothiazol resistance and impair the respiratory growth of the mutated strains abbeit maintaining a good electron transfer activity.酿酒酵母线粒体细胞色素b基因中同一位置的两个替换会诱导线粒体抗霉素A抗性,并损害突变菌株的呼吸生长,尽管保持了良好的电子传递活性。
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Functional characterization of the lesion in the ubiquinol: cytochrome c oxidoreductase complex isolated from the nonphotosynthetic strain R126 of Rhodobacter capsulatus.从荚膜红细菌非光合菌株R126中分离出的泛醇:细胞色素c氧化还原酶复合物中损伤的功能表征。
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氘代磷脂酰胆碱双层膜中泛醌位置与运动的1H-核磁共振研究
Biochim Biophys Acta. 1981 May 13;635(3):602-18. doi: 10.1016/0005-2728(81)90117-1.
4
Properties of a semiquinone anion located in the QH2:cytochrome c oxidoreductase segment of the mitochondrial respiratory chain.位于线粒体呼吸链QH2:细胞色素c氧化还原酶区段的半醌阴离子的性质。
FEBS Lett. 1980 Dec 15;122(1):143-8. doi: 10.1016/0014-5793(80)80422-4.
5
The distribution of ubiquinone-10 in phospholipid bilayers. A study using differential scanning calorimetry.辅酶Q10在磷脂双分子层中的分布。一项使用差示扫描量热法的研究。
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6
A redox study of the electron transport pathway responsible for generation of the slow electrochromic phase in chloroplasts.叶绿体中负责产生缓慢电致变色相的电子传递途径的氧化还原研究。
Biochim Biophys Acta. 1984 Oct 26;767(1):29-38. doi: 10.1016/0005-2728(84)90076-8.
7
Location of haem-binding sites in the mitochondrial cytochrome b.线粒体细胞色素b中血红素结合位点的位置
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8
Electron and proton transfers through quinones and cytochrome bc complexes.电子和质子通过醌类和细胞色素bc复合物的转移。
Biochim Biophys Acta. 1984 Apr 9;768(1):53-79. doi: 10.1016/0304-4173(84)90007-7.
9
Sequence homology and structural similarity between cytochrome b of mitochondrial complex III and the chloroplast b6-f complex: position of the cytochrome b hemes in the membrane.线粒体复合物III的细胞色素b与叶绿体b6-f复合物之间的序列同源性和结构相似性:细胞色素b血红素在膜中的位置。
Proc Natl Acad Sci U S A. 1984 Feb;81(3):674-8. doi: 10.1073/pnas.81.3.674.
10
Comparative aspects of quinol-cytochrome c/plastocyanin oxidoreductases.喹啉 - 细胞色素c/质体蓝素氧化还原酶的比较研究
Biochim Biophys Acta. 1983 Jul 15;726(2):97-133. doi: 10.1016/0304-4173(83)90002-2.