Nomura Eiji, Kayano Hajime, Lee Sang-Woong, Kawai Masaru, Machida Takashi, Yamamoto Soichiro, Nabeshima Kazuhito, Nakamura Kenji, Mukai Masaya, Uchiyama Kazuhisa
Department of Gastroenterological and General Surgery, Tokai University Hachioji Hospital, 1838 Ishikawa-machi, Hachioji, Tokyo, 192-0032, Japan.
Department of General and Gastroenterological Surgery, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki, Osaka, 569-8686, Japan.
Surg Today. 2019 Jan;49(1):38-48. doi: 10.1007/s00595-018-1699-7. Epub 2018 Aug 29.
Functional outcomes were prospectively compared between two types of reconstruction [double tract (L-DT; n = 15) and jejunal interposition (L-JIP; n = 15)] following laparoscopic half-proximal gastrectomy (LPG), including laparoscopic total gastrectomy (L-TG; n = 30) as a control group, at 1 year after surgery.
Clinical investigations were performed in each patient, and functional evaluations, involving the swallowing of an alimentary liquid containing acetaminophen (AAP), followed by measurements of the concentrations of AAP and hormones in the sitting (n = 5) and in the supine positions (n = 5), were carried out in each group.
The post-/preoperative body weight ratios were significantly higher in the L-DT and L-JIP groups than in the L-TG group. The AAP levels were significantly lower in the LPG group than in the LTG group. The AAP, insulin, and gastrin levels in the L-JIP group were markedly increased in the sitting position compared with the supine position, while those in the L-DT and L-TG groups were stable in both positions.
L-JIP and L-DT are procedures that maintain gradual intestinal absorption and help improve the quality of life. Intestinal absorption and hormonal secretion were relatively unaffected by the posture of the meal intake after L-DT, so L-DT might be the procedure providing the most stable results.
前瞻性比较腹腔镜半近端胃切除术(LPG)后两种重建方式[双通路(L-DT;n = 15)和空肠间置术(L-JIP;n = 15)]的功能结局,将腹腔镜全胃切除术(L-TG;n = 30)作为对照组,观察术后1年的情况。
对每位患者进行临床调查,并在每组中进行功能评估,包括吞咽含对乙酰氨基酚(AAP)的营养液,然后测量坐位(n = 5)和仰卧位(n = 5)时AAP和激素的浓度。
L-DT组和L-JIP组术后/术前体重比显著高于L-TG组。LPG组的AAP水平显著低于LTG组。与仰卧位相比,L-JIP组坐位时AAP、胰岛素和胃泌素水平显著升高,而L-DT组和L-TG组在两个体位下均保持稳定。
L-JIP和L-DT手术能维持肠道的逐步吸收并有助于改善生活质量。L-DT术后肠道吸收和激素分泌相对不受进餐姿势的影响,因此L-DT可能是效果最稳定的手术方式。