Lau J L, Fowler J E, Stobnicki M, Ray V, Forrest R
J Urol. 1986 Sep;136(3):715-8. doi: 10.1016/s0022-5347(17)45034-8.
We investigated the efficacy of kidney wrapping with polyglycolic acid (PGA) mesh for control of hemorrhage and preservation of renal function following extensive potentially lethal kidney lacerations in the dog. Wrapping of lacerated kidneys resulted in reapposition of the renal parenchyma and prompt, sustained hemostasis. At 21 days following injury the renal lacerations were well healed. Among five dogs with lacerations involving the entire surface of one kidney, the mean of the ratios of the creatinine clearance of the affected kidney divided by the creatinine clearance of the uninjured contralateral kidney was 0.83 +/- 0.14. Among ten dogs with lacerations confined to the lower pole of one kidney, five were treated by mesh wrapping and five by partial nephrectomy. The mean of the ratios of the creatinine clearance of the affected kidney divided by the creatinine clearance of the uninjured contralateral kidney was 0.93 +/- 0.17 for the former group and 0.58 +/- 0.06 for the latter group. Perirenal infection following kidney wrapping developed in only one dog who had an E. coli bacteriuria at the time of injury. Blood pressure was monitored in eight dogs treated with mesh wrapping. None became hypertensive. These data suggest that PGA mesh may have clinical utility in the management of selected renal injuries in humans.
我们研究了用聚乙醇酸（PGA）网包裹肾脏对犬类严重潜在致命性肾裂伤后控制出血和保护肾功能的疗效。包裹裂伤的肾脏可使肾实质重新贴合，并迅速、持续地止血。受伤21天后，肾裂伤愈合良好。在5只一侧肾脏整个表面都有裂伤的犬中，患侧肾脏肌酐清除率与未受伤对侧肾脏肌酐清除率之比的平均值为0.83±0.14。在10只一侧肾脏下极有裂伤的犬中，5只接受了网包裹治疗，5只接受了部分肾切除术。前一组患侧肾脏肌酐清除率与未受伤对侧肾脏肌酐清除率之比的平均值为0.93±0.17，后一组为0.58±0.06。仅1只在受伤时有大肠杆菌菌尿的犬在肾脏包裹后发生了肾周感染。对8只接受网包裹治疗的犬进行了血压监测。无一犬出现高血压。这些数据表明，PGA网在人类特定肾损伤的处理中可能具有临床应用价值。
